Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women
Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women
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DOI：
10.1038/sj.ijo.0802711
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发表时间：
2004-08-01
影响因子：
4.9
通讯作者：
Krebs, JD
中科院分区：
文献类型：
--
作者：
Browning, LM;Jebb, SA;Krebs, JD
目的：C反应蛋白（CRP）是许多疾病的预测因子，包括II型糖尿病和心血管疾病。较少的研究同样表明唾液酸（SA）是肥胖相关疾病的预测因子，但重要的是SA显示出比CRP更少的个体内变异性，并作为许多急性期蛋白活性的综合标志物。研究对象：共研究了257名女性，体重指数（BMI）范围为25.1 ~ 54.5 kg/m2（几何平均值33.1 ± 5.8 kg/m2），年龄19 ~ 71岁（平均值45.6 ± 12.1岁）。受试者没有并发感染的症状，已知的糖尿病，治疗血脂异常，慢性炎症状态，肝脏疾病或malignances.RESULTS：线性回归表明，CRP和SA与体重，BMI，胰岛素抵抗，血脂异常和高血压呈正相关。有高度显著性差异（P
AIMS: C-reactive protein (CRP) is a predictor of many diseases including type II diabetes and cardiovascular disease. Fewer studies have similarly shown sialic acid ( SA) to be a predictor of obesity-related diseases, but importantly SA shows less intraindividual variability than CRP and acts as an integrated marker of the activity of a number of acute-phase proteins. This study examines the association between both CRP and SA with individual and combined features of the metabolic syndrome.SUBJECTS: In all, 257 women with a body mass index (BMI) ranging from 25.1 to 54.5 kg/m(2) ( geometric mean 33.1 +/- 5.8 kg/m(2)) and aged 19 - 71 y (mean 45.6 +/- 12.1 y) were studied. Subjects had no symptoms of intercurrent infection, known diabetes, treated dyslipidaemia, a chronic inflammatory condition, liver disease or malignancy.RESULTS: Linear regression demonstrates that both CRP and SA were positively associated with weight, BMI, insulin resistance, dyslipidaemia and hypertension. There was a highly significant ( P