The formation of ternary complexes between VO(maltolate)2 and small bioligands
The formation of ternary complexes between VO(maltolate)2 and small bioligands
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VO(麦芽酸酯)2与小生物配体形成三元复合物
DOI：
10.1016/s0020-1693(98)00229-1
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
D. Sanna
中科院分区：
文献类型：
--
作者：
T. Kiss;E. Kiss;G. Micera;D. Sanna
为了评估VO（IV）以双（麦芽酚合）络合物（VO（麦芽）2）的形式施用时在生物体中的溶液状态，研究了VO（IV）-麦芽酚与各种生物配体（生物流体和组织的潜在金属离子结合剂）的三元体系，所述生物配体例如无机磷酸盐、腺苷核苷酸、儿茶酚衍生物、柠檬酸盐和草酸盐。通过pH电位法研究了VO（IV）在这些三元体系中的形态分布，同时通过光谱（UV-Vis和电子顺磁共振）方法确定了配合物的结合模式。这些结果有力地支持了VO（malt）2与生物体液和组织中的各种VO（IV）结合剂形成混合配体复合物的假设。
In order to assess the solution state of VO(IV) in organisms when administered in the form of the bis(maltolato) complex (VO(malt)2), ternary systems of VO(IV)—maltol with various bioligands (potential metal ion binders of biofluids and tissues), such as inorganic phosphates, adenosine nucleotides, catechol derivatives, citrate and oxalate, were studied. The speciation of VO(IV) in these ternary systems was studied by pH-potentiometry, while the binding modes of the complexes were determined by spectral (UV—Vis and electron paramagnetic resonance) methods. The results support strongly the assumption that VO(malt)2undergoes transformation into mixed ligand complexes formed with the various VO(IV) binders of biological fluids and tissues.