Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis.
Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis.
复制标题
IgG4相关呼吸系统疾病与结节病支气管肺泡灌洗液趋化因子谱比较：CC-趋化因子配体1可能参与结节病的发病机制。
DOI：
10.1016/j.cyto.2019.04.017
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发表时间：
2019
期刊：
影响因子：
3.8
通讯作者：
Hanaoka M.
中科院分区：
文献类型：
--
作者：
Yamamoto H;Yasuo M;Komatsu M;Ushiki A;Hamano H; Hori A;Nakajima T;Uehara T;Fujinaga Y;Matsui S;Hanaoka M.
我们之前报道过igg4相关呼吸系统疾病（IgG4-RRD）的支气管肺泡灌洗液（BALF）中的细胞因子谱比结节病更接近于t -辅助性（Th） 2反应。本研究旨在评估IgG4-RRD和结节病的BALF中的趋化因子，以评估这些趋化因子与其他标记物之间的可能关联。方法我们使用MILLIPLEX®MAP试剂盒（Millipore, Darmstadt, Germany）检测了相同的44例患者（IgG4-RRD, n = 11；结节病，n = 33）的相同BALF样本中的12种趋化因子，我们之前已经评估了这些细胞因子。结果IgG4-RRD患者BALF中cc -趋化因子配体（CCL）26水平（中位数24.5，范围3.1 ~ 401.1 pg/mL）显著高于结节病患者BALF（中位数3.1，范围3.1 ~ 155.6 pg/mL, p < 0.05）。有趣的是，结节病患者的CCL1 BALF水平（中位数13.1，范围0.1-106.9 pg/mL）显著高于IgG4-RRD患者（中位数9.8，范围0.1-14.7 pg/mL, p < 0.05）。此外,CCL1水平BALF中与细胞总数(ρ = 0.539,p < 0.001),淋巴细胞比例(R = 0.406,p < 0.05),淋巴细胞计数(R = 0.686,p < 0.001),肿瘤坏死因子-α水平,(R = 0.748,p < 0.001),和2级(R = 0.757,p < 0.001)BALF的结节病的病人。结论sccl1可能反映了结节病的活动性，其参与结节病的发病与Th1的关系可能比与Th2的关系更密切。
BackgroundWe previously reported that the cytokine profiles in the bronchoalveolar lavage fluid (BALF) of IgG4-related respiratory disease (IgG4-RRD) more closely resemble the T-helper (Th) 2 response than sarcoidosis. The present study aimed to assess the chemokines in the BALF of IgG4-RRD and sarcoidosis in order to evaluate any possible associations between these chemokines and other markers.MethodsWe examined 12 chemokines using a MILLIPLEX® MAP Kit (Millipore, Darmstadt, Germany) in the same BALF samples of the same 44 patients (IgG4-RRD, n = 11; sarcoidosis, n = 33) in which we had previously evaluated the cytokines.ResultsThe levels of CC-chemokine ligand (CCL)26 in the BALF of IgG4-RRD patients (median 24.5, range 3.1–401.1 pg/mL) were significantly higher than those in the BALF of sarcoidosis patients (median 3.1, range 3.1–155.6 pg/mL, p < 0.05). Interestingly, the BALF levels of CCL1 in the sarcoidosis patients (median 13.1, range 0.1–106.9 pg/mL) were significantly higher than those of the IgG4-RRD patients (median 9.8, range 0.1–14.7 pg/mL, p < 0.05). Furthermore, the CCL1 levels in the BALF were correlated with the total cell count (ρ = 0.539, p < 0.001), lymphocyte fraction (R = 0.406, P < 0.05), lymphocyte count (R = 0.686, P < 0.001), TNF-α level, (R = 0.748, P < 0.001), and IL-2 level (R = 0.757, P < 0.001) in the BALF of sarcoidosis patients.ConclusionsCCL1 might reflect disease activity and its involvement in the pathogenesis of sarcoidosis might be more closely related to Th1 than to Th2.