Beyond β-catenin: prospects for a larger catenin network in the nucleus.
Beyond β-catenin: prospects for a larger catenin network in the nucleus.
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DOI：
10.1038/nrm.2015.3
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Gottardi CJ
中科院分区：
文献类型：
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作者：
McCrea PD;Gottardi CJ
β-连环蛋白被广泛认为是经典WNT信号到核的主要转导子。在大多数脊椎动物中，有8个额外的连环蛋白在结构上与β-连环蛋白相关，并且有3个α-连环蛋白基因编码肌动蛋白结合蛋白，其在结构上与黏着斑蛋白相关。虽然这些连环蛋白最初被确定为与细胞连接处的钙粘蛋白相关，但最近的证据表明，大多数连环蛋白也定位于细胞核并调节基因表达。此外，据报道对典型WNT信号有反应的连环蛋白的数量正在增加。在这里，我们认为多个连环蛋白在细胞核中形成一个功能网络，可能参与保守的蛋白质-蛋白质相互作用，目前更好地表征在肌动蛋白为基础的细胞连接的背景下。
β-catenin is widely regarded as the primary transducer of canonical WNT signals to the nucleus. In most vertebrates, there are eight additional catenins that are structurally related to β-catenin, and three α-catenin genes encoding actin-binding proteins that are structurally related to vinculin. Although these catenins were initially identified in association with cadherins at cell–cell junctions, more recent evidence suggests that the majority of catenins also localize to the nucleus and regulate gene expression. Moreover, the number of catenins reported to be responsive to canonical WNT signals is increasing. Here, we posit that multiple catenins form a functional network in the nucleus, possibly engaging in conserved protein–protein interactions that are currently better characterized in the context of actin-based cell junctions.