Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis
Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis
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DOI：
10.1182/blood.v95.9.2943.009k17_2943_2946
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发表时间：
2000-05-01
期刊：
影响因子：
20.3
通讯作者：
Thrasher, AJ
中科院分区：
文献类型：
--
作者：
Lorenzi, R;Brickell, PM;Thrasher, AJ
Wiskott-Aldrich（WAS）蛋白（WASp）、小GTP酶和细胞骨架组织复合物Arp 2/3之间的相互作用似乎对于造血细胞中信号从细胞膜到肌动蛋白细胞骨架的转导至关重要。（Fc γ R）介导的吞噬作用在WASP缺陷型外周血单核细胞中受损，在巨噬细胞中受损，肌动蛋白杯的形成和酪氨酸磷酸化蛋白的局部募集显著减弱。结果还表明，在正常的巨噬细胞中，WASp本身被积极地募集到杯子中，这表明这种专门的细胞骨架结构的组装依赖于其表达。（血。2000;95：2943-2946）（C）2000由美国血液学学会。
Interactions between the Wiskott-Aldrich (WAS) protein (WASp), small GTPases, and the cytoskeletal organizing complex Arp2/3 appear to be critical for the transduction of signals from the cell membrane to the actin cytoskeleton in hematopoietic cells, This study shows that Fc gamma-receptor (Fc gamma R)-mediated phagocytosis is impaired in WASp-deficient peripheral blood monocytes, and that in macrophages, formation of the actin cup and local recruitment of tyrosine phosphorylated proteins is markedly attenuated. Results also show that, in normal macrophages, WASp itself is actively recruited to the cup, suggesting that assembly of this specialized cytoskeletal structure is dependent on its expression. (Blood. 2000;95:2943-2946) (C) 2000 by The American Society of Hematology.