Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors
Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors
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DOI：
10.1016/j.marenvres.2004.03.012
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发表时间：
2004-08-01
影响因子：
3.3
通讯作者：
Di Giulio, RT
中科院分区：
文献类型：
--
作者：
Wassenberg, DM;Di Giulio, RT
这些实验的目的是探讨细胞色素 P4501A (CYP1A) 诱导与来自大西洋木材工业超级基金地点（弗吉尼亚州伊丽莎白河）的沉积物在异斜管底胚胎中的致畸性之间的关系。在这些实验中，我们使用参考位点成虫产生的胚胎来评估伊丽莎白河沉积物水提取物 (ERSE) 诱导的 CYP1A 活性和致畸性。胚胎暴露于 ERSE 会诱导 CYP1A 活性并导致畸形，包括心包水肿、心脏伸长和尾部缩短。与各种 CYP1A 抑制剂共同暴露显着降低了 CYP1A 活性并增加了沉积物提取物的致畸性。本文讨论了这种毒性增加的潜在机制。 (C) 2004 Elsevier Ltd. 保留所有权利。
The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein. (C) 2004 Elsevier Ltd. All rights reserved.