Novel Insights into the Roles of Rho Kinase in Cancer.
Novel Insights into the Roles of Rho Kinase in Cancer.
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DOI：
10.1007/s00005-015-0382-6
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发表时间：
2016-08
影响因子：
3.2
通讯作者：
Shi J
中科院分区：
文献类型：
--
作者：
Wei L;Surma M;Shi S;Lambert-Cheatham N;Shi J
Rho相关螺旋卷曲蛋白激酶(ROCK)是小分子GTP酶RhoA的主要下游效应子。ROCK家族由ROCK1和ROCK2组成，在肌动蛋白细胞骨架的组织中发挥核心作用，并参与广泛的基本细胞功能，如收缩、黏附、迁移、增殖和凋亡。自从法舒地尔和Y27632等有效的抑制剂被发现以来，岩石在包括癌症在内的许多疾病中的生物学作用得到了广泛的研究。越来越多的证据支持这样的观点，即ROCK通过调节许多与恶性肿瘤相关的关键细胞功能，包括肿瘤的致瘤性、肿瘤的生长、转移、血管生成、肿瘤细胞的凋亡/存活和化疗耐药，在肿瘤的发生和发展中发挥重要作用。本文综述了近5年来有关ROCK在肿瘤发生发展中作用的研究进展，重点讨论了ROCK抑制剂在肿瘤治疗中的潜在价值。
Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in the organization of the actin cytoskeleton, and is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, proliferation, and apoptosis. Since the discovery of effective inhibitors such as fasudil and Y27632, the biological roles of ROCK have been extensively explored in numerous diseases, including cancer. Accumulating evidence supports the concept that ROCK plays important roles in tumor development and progression through regulating many key cellular functions associated with malignancy, including tumorigenicity, tumor growth, metastasis, angiogenesis, tumor cell apoptosis/survival and chemoresistance as well. This review focuses on the new advances of the most recent 5 years from the studies on the roles of ROCK in cancer development and progression; the discussion is mainly focused on the potential value of ROCK inhibitors in cancer therapy.