The role of psychological stress in inflammatory bowel disease
The role of psychological stress in inflammatory bowel disease
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DOI：
10.1159/000104861
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Rampton, David S.
中科院分区：
文献类型：
--
作者：
Mawdsley, Joel E.;Rampton, David S.
炎症性肠病（IBD）是一种胃肠道的特发性炎症性疾病，其自然史是缓解和复发期之一。病因学是复杂的，反映了基因和环境之间的相互作用。长期以来，医生和患者都报告说，心理压力会使IBD的疾病活动恶化。对疾病复发和不良生活事件之间关系的前瞻性研究产生了相互矛盾的结果，部分原因是这些研究固有的困难。然而，最近的几项分析表明，不良生活事件和慢性感知压力都可能导致疾病复发。还有越来越多的证据表明，实验性应激可以增加IBD患者和结肠炎动物模型的粘膜炎症。尽管对IBD中应激的促炎作用的理解有所增加，但到目前为止，只有少数有限的研究将减轻应激作为一种治疗方式进行了研究。版权所有（c）2006 S. Karger AG，巴塞尔。
Inflammatory bowel disease (IBD) is an idiopathic inflammatory condition of the gastrointestinal tract whose natural history is one of periods of remission and relapse. The aetiology is complex and reflects an interaction between genes and environment. Psychological stress has long been reported by both doctors and patients as worsening disease activity in IBD. Prospective studies of the relationship between disease relapse and adverse life events have produced conflicting results, in part due to the inherent difficulties of such studies. However, several more recent analyses have suggested that both adverse life events and chronic perceived stress can contribute to disease relapse. There is also an increasing body of evidence to suggest that experimental stress can increase mucosal inflammation both in patients with IBD and in animal models of colitis. Despite this increase in understanding the pro-inflammatory effects of stress in IBD, thus far only a few limited studies have examined stress reduction as a therapeutic modality. Copyright (c) 2006 S. Karger AG, Basel.