Atrial fibrillation predicts good functional outcome following intravenous tissue plasminogen activator in patients with severe stroke
Atrial fibrillation predicts good functional outcome following intravenous tissue plasminogen activator in patients with severe stroke
复制标题
DOI：
10.1016/j.clineuro.2012.08.034
复制
发表时间：
2013-07-01
影响因子：
1.9
通讯作者：
Lin, Huey-Juan
中科院分区：
文献类型：
--
作者：
Sung, Sheng-Feng;Chen, Yu-Wei;Lin, Huey-Juan
目的：静脉溶栓治疗后房颤（AF）预后不良，可能是由于治疗前卒中严重程度较高。我们进行了这项回顾性研究，以确定是否AF是一个独立的预测临床结果的患者分层的初始中风severity.Methods：共143例急性缺血性中风患者谁接受静脉溶栓后3小时内发病。根据基线时美国国立卫生研究院卒中量表（NIHSS）评分（10分）和是否存在AF对患者进行分类。结果：100例重度脑卒中患者（NIHSS评分> 10分）中，有房颤者（n = 52）90 d预后良好的比例高于无房颤者（31% vs. 8%，P = 0.005）。校正年龄、基线血糖水平和开始治疗时间后，差异仍然显著（比值比5.80，95%置信区间1.63 - 20.68）。轻度卒中患者（NIHSS
Objective: Atrial fibrillation (AF) is associated with poor outcome after intravenous thrombolysis probably due to greater pretreatment stroke severity. We conducted this retrospective study to determine whether AF is an independent predictor for clinical outcome in patients stratified by initial stroke severity.Methods: A total of 143 acute ischemic stroke patients who received intravenous thrombolysis within 3 h after onset were enrolled. The patients were categorized according to the baseline stroke severity by National Institute of Health Stroke Scale (NIHSS) score (10) and the presence of AF or not. Favorable 90-day outcome was defined as a modified Rankin Scale (mRS) score < 2.Results: Among the 100 patients with severe stroke (NIHSS > 10), those with AF (n = 52) had a higher proportion of favorable 90-day outcome than those without AF (31% vs. 8%, P = 0.005). After adjustment for age, baseline glucose level, and onset to treatment time, the difference remained significant (odds ratio 5.80, 95% confidence interval 1.63-20.68). In patients with mild stroke (NIHSS