Molecular evolution under fitness fluctuations.
Molecular evolution under fitness fluctuations.
复制标题
适应度波动下的分子进化。
DOI：
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发表时间：
2008
影响因子：
8.6
通讯作者：
M. Lässig
中科院分区：
文献类型：
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作者：
Ville Mustonen;M. Lässig
分子进化是一个随机过程，由种群中的适应性、突变和繁殖波动所控制。在这里，我们研究进化的适应性本身是随机的，在个别基因组位点的选择方向的随机开关。随着这些波动的相关时间变得大于种群内突变的扩散时间，适应度从退火随机变量变为淬火随机变量。我们表明，进化的速度有其最大的交叉制度，其中两个时间尺度是可比的。适应性进化出现在淬灭的适应性状态中（最近在基因组数据中发现了这种适应性波动的证据）。生殖和适应性波动的联合统计理论建立了进化遗传学和无序系统统计物理学之间的概念联系。
Molecular evolution is a stochastic process governed by fitness, mutations, and reproductive fluctuations in a population. Here, we study evolution where fitness itself is stochastic, with random switches in the direction of selection at individual genomic loci. As the correlation time of these fluctuations becomes larger than the diffusion time of mutations within the population, fitness changes from an annealed to a quenched random variable. We show that the rate of evolution has its maximum in the crossover regime, where both time scales are comparable. Adaptive evolution emerges in the quenched fitness regime (evidence for such fitness fluctuations has recently been found in genomic data). The joint statistical theory of reproductive and fitness fluctuations establishes a conceptual connection between evolutionary genetics and statistical physics of disordered systems.