Associations between skeletal muscle energetics and accelerometry-based performance fatigability: Study of Muscle, Mobility and Aging.
Associations between skeletal muscle energetics and accelerometry-based performance fatigability: Study of Muscle, Mobility and Aging.
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骨骼肌能量学与基于加速度测量的表现疲劳性之间的关联：肌肉、活动性和衰老的研究。
作者：
Qiao,YujiaSusanna;Santanasto,AdamJ;Coen,PaulM;Cawthon,PeggyM;Cummings,StevenR;Forman,DanielE;Goodpaster,BretH;Harezlak,Jaroslaw;Hawkins,Marquis;Kritchevsky,StephenB;Nicklas,BarbaraJ;Toledo,FredericoGS;Toto,PamelaE;New
表现疲劳通常表现为精力不足，无法完成日常体力活动，尤其是随着年龄的增长，通常会发展为依赖。因此，了解运动性疲劳的病因，特别是细胞水平的生物学机制，可能有助于延缓运动障碍的发生。我们假设骨骼肌能量学可能是疲劳表现的重要因素。肌肉、活动能力和衰老研究的参与者戴着腕部佩戴的ActiGraph GT9X完成了常规400米步行，以得出匹兹堡表现疲劳指数（PPFI，得分越高=疲劳程度越严重），该指数量化了个人节奏相对于时间轨迹从最大节奏下降的百分比。利用高分辨率呼吸测量法对股外侧肌活检的渗透纤维束进行体外定量分析，复合体i和ii支持的最大氧化磷酸化（max OXPHOS）和复合体i和ii支持的电子传递系统（max ETS）。用31p磁共振波谱法测定体内最大三磷酸腺苷产量（ATPmax）。我们进行了tobit回归，以检验最大OXPHOS、最大ETS和atpmax与PPFI的关系，调整了技术人员/地点、人口统计学特征和7天自由生活的老年人（N= 795, 70-94岁，58%女性）中PPFI评分完整且能量测量≥1的总活动量。PPFI评分中位数为1.4%[25 - 75百分位：0%-2.9%]。完全调整后，max OXPHOS、max ETS和atpmax每降低1个标准差，PPFI评分分别升高0.55 （95% CI: 0.26-0.84）、0.39 （95% CI: 0.09-0.70）和0.54 （95% CI: 0.27-0.81）。我们的研究结果表明，针对肌肉能量学的治疗可能潜在地减轻老年人的疲劳和减少对残疾的易感性。
Performance fatigability is typically experienced as insufficient energy to complete daily physical tasks, particularly with advancing age, often progressing toward dependency. Thus, understanding the etiology of performance fatigability, especially cellular‐level biological mechanisms, may help to delay the onset of mobility disability. We hypothesized that skeletal muscle energetics may be important contributors to performance fatigability. Participants in the Study of Muscle, Mobility and Aging completed a usual‐paced 400‐m walk wearing a wrist‐worn ActiGraph GT9X to derive the Pittsburgh Performance Fatigability Index (PPFI, higher scores = more severe fatigability) that quantifies percent decline in individual cadence‐versus‐time trajectory from their maximal cadence. Complex I&II‐supported maximal oxidative phosphorylation (max OXPHOS) and complex I&II‐supported electron transfer system (max ETS) were quantified ex vivo using high‐resolution respirometry in permeabilized fiber bundles from vastus lateralis muscle biopsies. Maximal adenosine triphosphate production (ATPmax) was assessed in vivo by31P magnetic resonance spectroscopy. We conducted tobit regressions to examine associations of max OXPHOS, max ETS, and ATPmaxwith PPFI, adjusting for technician/site, demographic characteristics, and total activity count over 7‐day free‐living among older adults (N= 795, 70–94 years, 58% women) with complete PPFI scores and ≥1 energetics measure. Median PPFI score was 1.4% [25th–75th percentile: 0%–2.9%]. After full adjustment, each 1 standard deviation lower max OXPHOS, max ETS, and ATPmaxwere associated with 0.55 (95% CI: 0.26–0.84), 0.39 (95% CI: 0.09–0.70), and 0.54 (95% CI: 0.27–0.81) higher PPFI score, respectively. Our findings suggested that therapeutics targeting muscle energetics may potentially mitigate fatigability and lessen susceptibility to disability among older adults.
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影响因子：
11.4
作者：
Nolfi-Donegan D;Braganza A;Shiva S
通讯作者：
Shiva S
DOI：
10.1093/gerona/glu134
发表时间：
2015-11-01
影响因子：
5.1
作者：
Santanasto, Adam J.;Glynn, Nancy W.;Newman, Anne B.
通讯作者：
Newman, Anne B.
影响因子：
9.8
作者：
Bua, Entela;Johnson, Jody;Aiken, Judd M.
通讯作者：
Aiken, Judd M.
DOI：
10.1093/gerona/gls196
发表时间：
2013-04-01
影响因子：
5.1
作者：
Coen, Paul M.;Jubrias, Sharon A.;Goodpaster, Bret H.
通讯作者：
Goodpaster, Bret H.
肌肉、活动能力和衰老研究 (SOMMA)。
DOI：
--
发表时间：
2023
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Steve Cummings;A. Newman;Paul M Coen;R. Hepple;Robin Collins;Kimberly Kennedy;M. Danielson;K. Peters;T. Blackwell;Eileen Johnson;T. Mau;E. Shankland;L. Lui;Sheena M Patel;Danielle Young;N. Glynn;E. Strotmeyer;K. Esser;D. Marcinek;B. Goodpaster;S. Kritchevsky;P. Cawthon
通讯作者：
P. Cawthon