INTESTINAL EPITHELIAL DAMAGE IN SIDS BABIES AND ITS SIMILARITY TO THAT CAUSED BY BACTERIAL TOXINS IN THE RABBIT
INTESTINAL EPITHELIAL DAMAGE IN SIDS BABIES AND ITS SIMILARITY TO THAT CAUSED BY BACTERIAL TOXINS IN THE RABBIT
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SIDS 婴儿的肠上皮损伤及其与细菌毒素引起的兔子损伤的相似性
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
W. G. Murrell
中科院分区：
文献类型：
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作者：
J. Kamaras;W. G. Murrell
对14例婴儿猝死综合征(SDS)患儿的十二指肠、空肠、回肠、盲肠和大肠进行了扫描和透射电子显微镜观察。对损害的类型和数量进行了表征和量化，并与婴儿粪便样本中的产气荚膜梭菌、艰难梭菌、大肠杆菌和金黄色葡萄球菌以及婴儿粪便样本和血清中的细菌毒素进行了比较。这些数据与这些毒素对兔肠道上皮造成的损害进行了比较(参见本期的前一篇论文)。大多数小岛屿发展中国家样本存在损害，从0到96%不等，大部分损害发生在粪便样本中含有上述细菌及其毒素时。损伤包括微绒毛的去除、绒毛尖端的破坏、固有层上皮细胞的分离和移除、离开杯状细胞和簇状细胞的肠细胞的去除，以及固有层的破坏和破坏。结果支持这样一种假设，即相当大比例的小岛屿发展中国家婴儿的死亡原因可能是从肠道吸收毒素引起的中毒性休克反应。
Summary Sections of the duodenum, jejunum, ileum, caecum and large intestine from 14 sudden infant death syndrome (SIDS) babies were examined by scanning (SEM) and transmission electron microscopy (TEM). The type and amount of damage was characterised and quantitated and compared with the presence of Clostridium perfringens, Clostridium difficile, Escherichia coli and Staphylococcus aureus in faecal samples from the babies and toxins from the bacteria in faecal samples and serum from the babies. The data were compared with the damage that these toxins cause to the rabbit intestinal epithelium (see the previous paper in this issue). Damage was present in most of the SIDS samples, varying from 0 to 96%, and most damage occurred when the faecal samples contained the above bacteria and their toxins. Damage varied from removal of microvilli, damage to villus tips, separation of and removal of epithelial cells from the lamina propria, and removal of enterocytes leaving goblet and tuft cells, to damage and breakdown of the lamina propria. The results support the hypothesis that the cause of death in a significant proportion of SIDS babies may result from the absorption of toxins from the intestinal tract initiating a toxic shock reaction.