Age at Menarche and Risks of Coronary Heart and Other Vascular Diseases in a Large UK Cohort
Age at Menarche and Risks of Coronary Heart and Other Vascular Diseases in a Large UK Cohort
复制标题
DOI：
10.1161/circulationaha.114.010070
复制
发表时间：
2015-01-20
期刊：
影响因子：
37.8
通讯作者：
Cairns, Benjamin J.
中科院分区：
文献类型：
--
作者：
Canoy, Dexter;Beral, Valerie;Cairns, Benjamin J.
背景-初潮早与冠心病（CHD）风险增加有关，但大多数研究相对较小，无法评估大范围初潮年龄的风险;很少有研究与其他血管疾病的相关性。我们研究了CHD，脑血管疾病，高血压疾病的风险，在月经初潮的年龄在一个大型的前瞻性研究的英国women.Methods和结果，在120万妇女（平均+/- SD年龄，56 +/- 5岁）没有以前的心脏病，中风，或癌症，月经初潮年龄被报道为13岁的25%，= 17岁的1%。经过11.6年的随访，73378名妇女首次住院或死于冠心病，25426名死于脑血管病，249426名死于高血压病。使用考克斯回归，我们计算了每种血管结局的相对风险，以月经初潮年龄为单位。冠心病与冠状动脉狭窄的关系呈U型。与13岁时初潮的女性相比，
Background-Early menarche has been associated with increased risk of coronary heart disease (CHD), but most studies were relatively small and could not assess risk across a wide range of menarcheal ages; few have examined associations with other vascular diseases. We examined CHD, cerebrovascular disease, and hypertensive disease risks by age at menarche in a large prospective study of UK women.Methods and Results-In 1.2 million women (mean +/- SD age, 56 +/- 5 years) without previous heart disease, stroke, or cancer, menarcheal age was reported to be 13 years by 25%, = 17 years by 1%. After 11.6 years of follow-up, 73 378 women had first hospitalization for or death from CHD, 25 426 from cerebrovascular disease, and 249 426 from hypertensive disease. Using Cox regression, we calculated relative risks for each vascular outcome by single year of menarcheal age. The relationship was U-shaped for CHD. Compared with women with menarche at 13 years, the adjusted relative risk for CHD for menarche at