The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.
复制标题
DOI：
10.1038/s41375-022-01613-1
复制
发表时间：
2022-07
期刊：
影响因子：
11.4
通讯作者：
Hochhaus, Andreas
中科院分区：
文献类型：
--
作者：
Khoury, Joseph D.;Solary, Eric;Abla, Oussama;Akkari, Yassmine;Alaggio, Rita;Apperley, Jane F.;Bejar, Rafael;Berti, Emilio;Busque, Lambert;Chan, John K. C.;Chen, Weina;Chen, Xueyan;Chng, Wee-Joo;Choi, John K.;Colmenero, Isabel;Coupland, Sarah E.;Cross, Nicholas C. P.;De Jong, Daphne;Elghetany, M. Tarek;Takahashi, Emiko;Emile, Jean-Francois;Ferry, Judith;Fogelstrand, Linda;Fontenay, Michaela;Germing, Ulrich;Gujral, Sumeet;Haferlach, Torsten;Harrison, Claire;Hodge, Jennelle C.;Hu, Shimin;Jansen, Joop H.;Kanagal-Shamanna, Rashmi;Kantarjian, Hagop M.;Kratz, Christian P.;Li, Xiao-Qiu;Lim, Megan S.;Loeb, Keith;Loghavi, Sanam;Marcogliese, Andrea;Meshinchi, Soheil;Michaels, Phillip;Naresh, Kikkeri N.;Natkunam, Yasodha;Nejati, Reza;Ott, German;Padron, Eric;Patel, Keyur P.;Patkar, Nikhil;Picarsic, Jennifer;Platzbecker, Uwe;Roberts, Irene;Schuh, Anna;Sewell, William;Siebert, Reiner;Tembhare, Prashant;Tyner, Jeffrey;Verstovsek, Srdan;Wang, Wei;Wood, Brent;Xiao, Wenbin;Yeung, Cecilia;Hochhaus, Andreas
即将发布的第五版世界卫生组织（WHO）血淋巴瘤分类是在一个单一的关系数据库中对各种器官系统中出现的人类癌症进行分级分类的努力的一部分。本文总结了新的世卫组织髓系和组织细胞/树突状肿瘤分类方案，并提供了一个概述的原则和基本原理的变化，从以前的版本。疾病类型的定义和诊断仍然基于多种临床病理学参数，但需要细化诊断标准，并强调治疗和/或诊断上可行的生物标志物。虽然尽可能寻求确定疾病的遗传学基础，但分类努力保持世界范围的实际适用性。其结果是骨髓和组织细胞/树突状肿瘤的增强的，当代的，基于证据的分类，植根于分子生物学和组织结构，允许未来的可扩展性，因为新的发现继续无情地告知未来的版本。
The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.
登录
查看更多内容
影响因子：
82.9
作者：
Bernard E;Nannya Y;Hasserjian RP;Devlin SM;Tuechler H;Medina-Martinez JS;Yoshizato T;Shiozawa Y;Saiki R;Malcovati L;Levine MF;Arango JE;Zhou Y;Solé F;Cargo CA;Haase D;Creignou M;Germing U;Zhang Y;Gundem G;Sarian A;van de Loosdrecht AA;Jädersten M;Tobiasson M;Kosmider O;Follo MY;Thol F;Pinheiro RF;Santini V;Kotsianidis I;Boultwood J;Santos FPS;Schanz J;Kasahara S;Ishikawa T;Tsurumi H;Takaori-Kondo A;Kiguchi T;Polprasert C;Bennett JM;Klimek VM;Savona MR;Belickova M;Ganster C;Palomo L;Sanz G;Ades L;Della Porta MG;Elias HK;Smith AG;Werner Y;Patel M;Viale A;Vanness K;Neuberg DS;Stevenson KE;Menghrajani K;Bolton KL;Fenaux P;Pellagatti A;Platzbecker U;Heuser M;Valent P;Chiba S;Miyazaki Y;Finelli C;Voso MT;Shih LY;Fontenay M;Jansen JH;Cervera J;Atsuta Y;Gattermann N;Ebert BL;Bejar R;Greenberg PL;Cazzola M;Hellström-Lindberg E;Ogawa S;Papaemmanuil E
通讯作者：
Papaemmanuil E
影响因子：
11.4
作者：
Bruford EA;Antonescu CR;Carroll AJ;Chinnaiyan A;Cree IA;Cross NCP;Dalgleish R;Gale RP;Harrison CJ;Hastings RJ;Huret JL;Johansson B;Le Beau M;Mecucci C;Mertens F;Verhaak R;Mitelman F
通讯作者：
Mitelman F
影响因子：
10.1
作者：
Behrens YL;Göhring G;Bawadi R;Cöktü S;Reimer C;Hoffmann B;Sänger B;Käfer S;Thol F;Erlacher M;Niemeyer CM;Baumann I;Kalb R;Schindler D;Kratz CP
通讯作者：
Kratz CP
影响因子：
14.2
作者：
Alvarez-Twose, Ivan;Jara-Acevedo, Maria;Escribano, Luis
通讯作者：
Escribano, Luis
影响因子：
20.3
作者：
Chan, John K. C.;Lamant, Laurence;Chow, Chung W.
通讯作者：
Chow, Chung W.