Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer.
Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer.
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DOI：
10.1155/2012/213492
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发表时间：
2012
影响因子：
--
通讯作者：
Shinomiya H
中科院分区：
文献类型：
--
作者：
Shinomiya H
各种肌动蛋白结合蛋白对肌动蛋白细胞骨架的复杂调控是真核细胞发挥其多种功能所必需的。活质蛋白家族属于肌动蛋白捆绑蛋白，该蛋白家族在进化上是保守的，在酵母、植物和动物细胞中均有表达。塑性蛋白的特征是EF-hand Ca2+结合域和肌动蛋白结合域，并且可以将肌动蛋白丝交联成高阶组装，如束。在哺乳动物中已鉴定出三种同种异构体。T-plastin在来自实体组织的细胞中表达，比如大脑中的神经元。I-plastin的表达仅限于肠和肾；同种异构体在这些器官的吸收上皮的功能中起着至关重要的作用。L-plastin在造血细胞系和许多类型的癌细胞中表达；因此，该异构体被认为是一种有用的癌症生物标志物。
Sophisticated regulation of the actin cytoskeleton by a variety of actin-binding proteins is essential for eukaryotic cells to perform their diverse functions. The plastin (also know, as fimbrin) protein family belongs to actin-bundling proteins, and the protein family is evolutionarily conserved and expressed in yeast, plant, and animal cells. Plastins are characterized by EF-hand Ca2+-binding domains and actin-binding domains and can cross-link actin filaments into higher-order assemblies like bundles. Three isoforms have been identified in mammals. T-plastin is expressed in cells from solid tissues, such as neurons in the brain. I-plastin expression is restricted to intestine and kidney; the isoform plays a vital role in the function of absorptive epithelia in these organs. L-plastin is expressed in hematopoietic cell lineages and in many types of cancer cells; the isoform is thus considered to be a useful biomarker for cancer.