Smoking habits and risk of fatal stroke: 18 years follow up of the Oslo study
Smoking habits and risk of fatal stroke: 18 years follow up of the Oslo study
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DOI：
10.1136/jech.50.6.621
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发表时间：
1996-12-01
影响因子：
6.3
通讯作者：
Leren, P
中科院分区：
文献类型：
--
作者：
Haheim, LL;Holme, I;Leren, P
研究目的-检查致命性中风的风险与男性吸烟习惯筛选的奥斯陆study.Design -该奥斯陆研究是一个前瞻性的，队列研究的流行病学和预防方面的心血管疾病的中年男子。筛选开始于1972年5月和18年后的后续结果reported.Participants -有16209名男性年龄在40-49岁，其中16173没有中风史。85例男性死于中风，其中48例为每日吸烟者，7例为烟斗和雪茄吸烟者，15例为每日吸烟和烟斗或雪茄吸烟者，II例为既往吸烟者，4例从未吸烟。和葡萄糖浓度显示以下速率比（RR）（95%置信区间）吸烟组与从不吸烟或以前吸烟者相比：香烟和雪茄或烟斗吸烟者，RR = 6.1（3.0，12.5）;仅香烟RR = 4.1（2.3，7.4）;仅烟斗和/或雪茄RR = 2.2（0.9，5.5）。总体而言，每天吸烟的年龄调整风险为3.5，并发现随着卷烟消费量的增加而增加。与未患中风的男性相比，无论其吸烟组如何，中风病例的舒张压（DBP）和收缩压（SEP）均升高。卒中病例和其他从不吸烟和既往吸烟者与每日吸烟者之间DBP和SEP的绝对差异是两倍大：DBP分别为12.1 mmHg与6.5 mmHg，SEP分别为16.0 mmHg与7.1 mmHg。高BMI增加了从未吸烟者和以前吸烟者致命性中风的风险。在筛选时接受高血压治疗的男性，其致命性中风的粗风险是未接受高血压治疗的男性的3倍。结论：每天吸烟使致命性中风的风险增加3.5倍。香烟和烟斗或雪茄的混合吸烟比只吸烟的风险更高。发现增加的风险与每日吸烟量增加有关。
Study objective - To examine the risk of fatal stroke in relation to smoking habits in men screened for the Oslo study.Design - The Oslo study is a prospective, cohort study of the epidemiology and preventive aspects of cardiovascular diseases in middle aged men. Screening started in May 1972 and results after 18 years of follow up are reported.Participants - There were 16 209 men aged 40-49 years, of whom 16 173 had no stroke history. Eighty five men died from stroke, of whom 48 were daily cigarettes smokers, 7 were pipe and cigar smokers, 15 smoked cigarettes and pipe or cigars daily, II were previous cigarette smokers, and 4 had never smoked cigarettes.Main results - Results of proportional hazards regression analysis adjusted for age, diastolic blood pressure, and glucose concentration showed the following rate ratios (RR) (95% confidence interval) of smoking groups compared with those who had never smoked or had previously smoked: combined cigarette and cigar or pipe smokers, RR = 6.1 (3.0,12.5); cigarettes only, RR = 4.1 (2.3,7.4); and pipe and/or cigars only RR = 2.2 (0.9,5.5). The overall, age adjusted risk of smoking cigarettes daily was 3.5 and was found to increase with increasing cigarette consumption. Regardless of their smoking group, stroke cases had increased diastolic (DBP) and systolic blood pressure (SEP) when compared with men who had not had a stroke. The absolute differences in DBP and SEP between stroke cases and others for never and previous cigarette smokers versus daily smokers were twice as large: DBP, 12.1 mmHg versus 6.5 mmHg respectively and SEP, 16.0 mmHg versus 7.1 mmHg respectively. A high BMI increased the risk of fatal stroke of never and previous cigarette smokers. Men being treated for hypertension at the time of screening had three times the crude risk of fatal stroke of men who were not taking hypertensive treatment.Conclusions - Daily cigarette smoking increased the risk of fatal stroke three and a half times. Combined cigarette and pipe or cigar smoking had a higher risk than smoking cigarettes only. An increased risk was found in relation to increased daily cigarette consumption.