Morphological changes of skeletal muscle, tendon and periosteum in the senescence-accelerated mouse (SAMP6): A murine model for senile osteoporosis
Morphological changes of skeletal muscle, tendon and periosteum in the senescence-accelerated mouse (SAMP6): A murine model for senile osteoporosis
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DOI：
10.1016/j.tice.2006.08.001
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发表时间：
2006-10-01
期刊：
影响因子：
2.6
通讯作者：
Shoumura, S.
中科院分区：
文献类型：
--
作者：
Chen, H.;Yao, X. F.;Shoumura, S.
SAMP 6是快速老化小鼠的一个亚系，可作为老年性骨质疏松症的动物模型。之前，我们在SAMP 6中观察到了与年龄相关的骨骼变化。在本研究中，我们研究了骨骼肌，肌腱和骨膜在SAMP 6和年龄匹配的正常小鼠SAMR 1的形态。我们没有发现SAMR 1和SAMP 6之间在1和2个月大的任何显着差异。与SAMR 1相比，在8月龄时，SAMP 6比目鱼肌的I型和11型肌纤维的横截面积显著降低。在8月龄的SAMP 6中，肌肉-肌腱交界处的界面中的投影显著减少。8月龄时，SAMP 6组跟腱纤维中成纤维细胞的数量和腱胶原纤维的直径显著减少。SAMP 6的Sharpey纤维直径在5月龄和8月龄时减小。在5月龄和8月龄的SAMP 6中，跟腱止点中的一些软骨细胞和骨膜中的一些成骨细胞显示退行性变化。随着年龄的增长，骨骼肌、肌腱连接处、肌腱、腱骨界面和骨膜发生明显的退行性变化。提示SAMP 6小鼠骨骼肌萎缩、肌腱和骨膜变性，可能参与了老年性骨质疏松症的骨丢失。(c)2006爱思唯尔有限公司保留所有权利。
SAMP6, a substrain of senescence-accelerated mouse, was developed as an animal model for senile osteoporosis. Previously we observed age-related changes of the bone in SAMP6. In the present study, we investigated the morphology of the skeletal muscle, tendon and periosteum in SAMP6 and age-matched normal mouse SAMR1. We did not find any significant differences between SAMR1 and SAMP6 at I and 2 months of age. As compared with SAMR1, the cross-sectional area of type I and type 11 muscle fibers of the soleus muscle were significantly low in SAMP6 at 8 months of age. The projections in the interface of the muscle-tendon junctions were significantly decreased in SAMP6 at 8 months of age. The number of fibroblasts and the diameter of the tendon collagen fibers in Achilles fiber were significantly reduced in SAMP6 at 8 months of age. The diameter of Sharpey's fiber reduced in SAMP6 at 5 and 8 months of age. Some chondrocytes in the insertions of Achilles tendon and some osteogenic cells in the periosteum showed degenerative changes in SAMP6 at 5 and 8 months of age. The pronounced degenerative changes were detected in the skeletal muscle, muscle-tendon junction, tendon, tendon-bone interface and periosteum in SAMP6 with age. These findings indicated the atrophy of skeletal muscle, degeneration of tendon and periosteum in SAMP6, which may be involved in the bone loss for senile osteoporosis. (c) 2006 Elsevier Ltd. All rights reserved.