Chronic Medical Conditions as Risk Factors for Herpes Zoster
Chronic Medical Conditions as Risk Factors for Herpes Zoster
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DOI：
10.1016/j.mayocp.2012.05.021
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发表时间：
2012-10-01
影响因子：
8.9
通讯作者：
Bialek, Stephanie R.
中科院分区：
文献类型：
--
作者：
Joesoef, Riduan M.;Harpaz, Rafael;Bialek, Stephanie R.
目的：为了确定在何种程度上，慢性疾病可能会导致无法解释的负担带状疱疹。方法：我们进行了一项病例对照研究，使用市场扫描数据从2007年1月1日至2007年12月31日，调查慢性疾病的危险因素带状疱疹的人20至64岁。病例是诊断为带状疱疹的入组者（国际疾病分类，第九次修订，临床修改代码053.xx），对照组是没有带状疱疹诊断的患者，按年龄组和保险计划匹配。我们选择了10种慢性疾病，根据其在一般人群中的患病率。我们计算了归因分数，并通过对慢性疾病的显著回归系数求和来创建共病综合评分。我们使用逻辑回归来评估带状疱疹和慢性病之间的关联。结果：我们确定了59,173例病例和616,177例对照进行分析。10种研究条件中有8种带状疱疹风险显著（比值比，1.06-1.52）。带状疱疹风险也随着合并症综合评分的增加而增加。这8种重要疾病的归因分数范围为0.24%至2.89%。结论：慢性病患者患带状疱疹的风险可能会增加。然而，这种风险可能不会对人群中带状疱疹的负担产生实质性影响。大多数带状疱疹病例的原因仍然未知。(C)2012年马约医学教育和研究基金会广场马约临床程序。2012：87（10）961-967
Objective: To determine the degree to which chronic conditions might contribute to the unexplained burden of herpes zoster.Methods: We conducted a case-control study using Market Scan data from January 1, 2007, through December 31, 2007, to investigate chronic conditions as risk factors for herpes zoster among persons 20 to 64 years old. Cases were enrollees with a herpes zoster diagnosis (International Classification of Diseases, Ninth Revision, Clinical Modification codes 053.xx), and controls were those without a herpes zoster diagnosis, matched by age groups and insurance plan. We selected 10 chronic conditions based on their prevalence in the general population. We calculated the attributable fraction and created a comorbidity composite score by summing the significant coefficient of regression of chronic conditions. We used logistic regression to evaluate the associations between herpes zoster and chronic conditions.Results: We identified a total of 59,173 cases and 616,177 controls for the analysis. Risk of herpes zoster was significant for 8 of the 10 study conditions (odds ratios, 1.06-1.52). Herpes zoster risk also increased as a function of comorbidity composite score. The attributable fractions for these 8 significant conditions ranged from 0.24% to 2.89%.Conclusion: The risk of herpes zoster may be increased in people with chronic conditions. However, this risk may not contribute substantially to the burden of herpes zoster in the population. The causes for most cases of herpes zoster remain unknown. (C) 2012 Mayo Foundation for Medical Education and Research square Mayo Clin Proc. 2012:87(10)961-967