Role of spinal cord glia in the central processing of peripheral pain perception.
Role of spinal cord glia in the central processing of peripheral pain perception.
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DOI：
10.1111/j.1365-2982.2010.01491.x
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发表时间：
2010-05
影响因子：
3.5
通讯作者：
Bradesi S
中科院分区：
文献类型：
--
作者：
Bradesi S
神经胶质细胞激活在神经元功能的调节中起着关键作用，并影响伤害性信号的脊髓处理，这一发现使人们对慢性疼痛易化中涉及的中枢敏化机制有了新的认识。脊髓神经胶质细胞激活现在被认为是各种慢性疼痛模型中异常性疼痛和痛觉过敏的发展和维持的重要组成部分，包括神经性疼痛和与外周炎症相关的疼痛。此外，脊髓胶质细胞的激活也参与了某些形式的内脏痛觉过敏。我们讨论了参与中央胶质细胞激活的信号通路，包括应激通路，以及参与突触活动和疼痛促进的调节的神经元-胶质细胞双向关系。在这一不断扩大的研究领域中，胶质细胞影响脊髓神经传递的机制的表征将增加我们对中枢疼痛促进的理解，并有可能为常见的慢性疼痛疾病开发新的治疗药物。
The discovery that glial activation plays a critical role in the modulation of neuronal functions and affects the spinal processing of nociceptive signalling has brought new understanding on the mechanisms underlying central sensitization involved in chronic pain facilitation. Spinal glial activation is now considered an important component in the development and maintenance of allodynia and hyperalgesia in various models of chronic pain, including neuropathic pain and pain associated with peripheral inflammation. In addition, spinal glial activation is also involved in some forms of visceral hyperalgesia. We discuss the signalling pathways engaged in central glial activation, including stress pathways, and the neuron-glia bidirectional relationships involved in the modulation of synaptic activity and pain facilitation. In this expanding field of research, the characterization of the mechanisms by which glia affect spinal neuro-transmission will increase our understanding of central pain facilitation, and has the potential for the development of new therapeutic agents for common chronic pain conditions.
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DOI：
10.1073/pnas.81.21.6890
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
FYFFE, REW;PERL, ER
通讯作者：
PERL, ER
影响因子：
2.1
作者：
Davidson, Tatiana M.;Cardemil, Esteban V.
通讯作者：
Cardemil, Esteban V.
影响因子：
29.4
作者：
Bradesi S;Svensson CI;Steinauer J;Pothoulakis C;Yaksh TL;Mayer EA
通讯作者：
Mayer EA
影响因子：
56.9
作者：
Beattie, EC;Stellwagen, D;Malenka, RC
通讯作者：
Malenka, RC
影响因子：
9.8
作者：
D'Mello, R.;Dickenson, A. H.
通讯作者：
Dickenson, A. H.