Six Month Follow-up of Patients With Multi-System Inflammatory Syndrome in Children
Six Month Follow-up of Patients With Multi-System Inflammatory Syndrome in Children
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DOI：
10.1542/peds.2021-050973
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发表时间：
2021-10-01
期刊：
影响因子：
8
通讯作者：
Mitchell, Elizabeth
中科院分区：
文献类型：
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作者：
Capone, Christine A.;Misra, Nilanjana;Mitchell, Elizabeth
背景和目的：心肌功能障碍和冠状动脉异常是儿童多系统炎症综合征的显著特征。在这项研究中，我们旨在评估管理信息系统C的早期和中期结果。方法：这是一项为期6个月的纵向队列研究，研究对象为2020年4月17日至6月20日期间所有因管理信息系统C入院并接受治疗的儿童。结果：急性期31例(62%)患者需要血管活性支持，26例(52%)左心室收缩功能不全，16例(32%)左室舒张功能不全，8例(16%)冠状动脉瘤(z记分=2.5)，4例(8%)冠状动脉扩张
BACKGROUND AND OBJECTIVES: Myocardial dysfunction and coronary abnormalities are prominent features of multisystem inflammatory syndrome in children (MIS-C). In this study we aim to evaluate the early and midterm outcomes of MIS-C.METHODS: This is a longitudinal 6-month cohort study of all children admitted and treated for MIS-C from April 17 to June 20, 2020. Patients were followed similar to 2 weeks, 8 weeks, and 6 months postadmission, with those with coronary aneurysms evaluated more frequently.RESULTS: Acutely, 31 (62%) patients required intensive care with vasoactive support, 26 (52%) had left ventricular (LV) systolic dysfunction, 16 (32%) had LV diastolic dysfunction, 8 (16%) had coronary aneurysms (z score >= 2.5), and 4 (8%) had coronary dilation (z score