Age-related hearing loss is strongly associated with cognitive decline regardless of the APOE4 polymorphism
Age-related hearing loss is strongly associated with cognitive decline regardless of the APOE4 polymorphism
复制标题
无论 APOE4 多态性如何，年龄相关的听力损失与认知能力下降密切相关
DOI：
10.1097/mao.0000000000002415
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Horii A.
中科院分区：
文献类型：
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作者：
Morita Y;Sasaki T;Takahashi K;Kitazawa M;Nonomura Y;Yagi C;Yamagishi T;Ohshima S;Izumi S;Wakasugi M;Yokoseki A;Narita I;Endo N;Horii A.
目的：探讨老年性耳聋患者听力损伤与认知功能下降的关系，并确定老年性耳聋的危险因素。研究设计：前瞻性队列研究中的横断面调查。地点：大学医院。患者：共322名年龄> 60岁的参与者，他们的以下数据均可用。有168名女性和154名男性，中位年龄为71岁（范围：60-89岁）。干预措施：PROST（佐渡岛全面健康项目），在佐渡岛日本的医学数据库，进行了分析。主要结果措施：数据纯音测听，简易精神状态检查（MMSE），载脂蛋白E4（ApoE 4）的多态性，糖尿病，高血压，吸烟，饮酒被提取。听力障碍被定义为平均频率在0.25和8 kHz之间，超过30 dB。采用多因素分析确定上述因素中哪些因素可以预测听力损伤。结果：在各种因素中，只有MMSE评分低（< 24分）与听力障碍有显著相关性。ApoE状态groups.Conclusions之间的所有频率的听力阈值没有差异：听力障碍与低MMSE疼痛，无论ApoE 4状态。如果ApoE 4状态是听力和认知障碍的共同上游预测因子，则听力阈值将与ApoE 4状态相关。然而，这些结果可能表明，听力障碍可能与认知功能障碍有因果关系，可能通过认知负荷机制。
Objective:To examine the association between hearing impairment and cognitive decline and to identify possible risk factors for presbycusis.Study Design:Cross-sectional survey in prospective cohort study.Setting:University hospital.Patients:A total of 322 participants aged> 60 years, for whom all the below data were available, were enrolled in the study. There were 168 females and 154 males with a median age of 71 years (range: 60–89 yrs).Interventions:PROST (Project in Sado for Total Health), a medical database in Sado island Japan, was analyzed.Main Outcome Measures:Data on pure-tone audiometry, mini-mental state examination (MMSE), polymorphism of apolipoprotein E4 (ApoE4), diabetes mellitus, hypertension, smoking, and alcohol consumption were extracted. Hearing impairment was defined as an average frequency between 0.25 and 8 kHz that exceeded 30 dB. Multivariate analysis was used to identify which of the above factors could predict the hearing impairment. Hearing threshold of each Hz was compared between the ApoE4 (+/+),(+/−), and (−/−) groups.Results:Among various factors, only low MMSE scores (< 24) showed significant association with hearing impairment. There were no differences in the hearing threshold of all frequencies between ApoE status groups.Conclusions:Hearing impairment was associated with low MMSE sores, regardless of the ApoE4 status. If ApoE4 status would be a common upstream predictor for both the hearing and cognitive impairment, hearing threshold would be related to ApoE4 status. However, these results may suggest that hearing impairment may be causally related to the cognitive dysfunction, perhaps via the cognitive load mechanisms.