Cell adhesion molecules in early chicken embryogenesis.
Cell adhesion molecules in early chicken embryogenesis.
复制标题
早期鸡胚胎发生中的细胞粘附分子。
DOI：
10.1073/pnas.79.21.6737
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发表时间：
1982
影响因子：
11.1
通讯作者：
Edelman,GM
中科院分区：
文献类型：
--
作者：
Thiery,JP;Duband,JL;Rutishauser,U;Edelman,GM
通过荧光抗体技术，在早期（1-5 天）鸡胚胎的多个区域中发现了 N-CAM（神经细胞粘附分子）。这些区域似乎与初级发育轴的诱导有关（神经板、神经管、脊索、体节）或随后发生诱导事件的区域（神经嵴细胞、视、耳和咽基板、心脏中胚层、中肾原基、肢芽）。后一组区域的染色模式是高度动态和短暂的，并且仅限于基板的上皮成分和中肾小管的前体。在神经嵴细胞中，N-CAM 出现较早，在细胞在纤连蛋白上迁移过程中消失，并在神经节形成的部位重新出现。在神经系统的其他区域，特别是与神经管直接相关的区域，N-CAM 分子在所有阶段都会被染色。这些结果提出了 N-CAM 介导的粘附在早期胚胎发生以及后期组织发生中发挥主要作用的可能性。
N-CAM, the neural cell adhesion molecule, has been found at a number of regions in the early (1-5 days) chicken embryo by fluorescent antibody techniques. These regions appear to be those concerned with induction of the primary developmental axis (neural plate, neural tube, notochord, somites) or those in which later inductive events occur (neural crest cells, optic, otic, and pharyngeal placodes, cardiac mesoderm, mesonephric primordium, limb buds). The staining patterns in the latter group of regions are highly dynamic and transient and are limited to the epithelial components of the placodes and to the precursors of mesonephric tubules. In neural crest cells, N-CAM appears early, disappears during migration of the cells on fibronectin, and reappears at sites where ganglia are formed. In other regions of the nervous system, particularly those related directly to the neural tube, the N-CAM molecule is stained at all stages. The results raise the possibility that adhesion mediated by N-CAM plays a primary role in early embryogenesis as well as in later histogenesis.