Brain gene expression during REM sleep depends on prior waking experience
Brain gene expression during REM sleep depends on prior waking experience
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DOI：
10.1101/lm.6.5.500
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发表时间：
1999-09-01
影响因子：
2
通讯作者：
Pavlides, C
中科院分区：
文献类型：
--
作者：
Ribeiro, S;Goyal, V;Pavlides, C
在大多数哺乳动物物种的研究，两个不同的和连续的睡眠阶段，慢波（SW），和快速眼动（REM），可以识别的基础上，他们的脑电图配置文件和相关的行为。这两个阶段都与白天事件的离线感觉运动处理有关，但分子机制仍然难以捉摸。我们研究了大脑的可塑性相关的立即早期基因（IEG）zif-268在SW和REM睡眠大鼠暴露于丰富的感觉运动的经验在前清醒期。而未暴露的对照组在SW和. REM睡眠，zif-268在REM睡眠期间在暴露动物的大脑皮层和海马体中上调。我们认为，这种现象代表了一个窗口，增加神经元可塑性在快速眼动睡眠丰富的清醒经验。
In most mammalian species studied, two distinct and successive phases of sleep, slow wave (SW), and rapid eye movement (REM), can be recognized on the basis of their EEG profiles and associated behaviors. Both phases have been implicated in the offline sensorimotor processing of daytime events, but the molecular mechanisms remain elusive. We studied brain expression of the plasticity-associated immediate-early gene (IEG) zif-268 during SW and REM sleep in rats exposed to rich sensorimotor experience Ln the preceding waking period. Whereas nonexposed controls show generalized zif-268 down-regulation during SW and. REM sleep, zif-268 is upregulated during REM sleep in the cerebral cortex and the hippocampus of exposed animals. We suggest that this phenomenon represents a window of increased neuronal plasticity during REM sleep that follows enriched waking experience.