Evolutionary direction of processed pseudogenes
Evolutionary direction of processed pseudogenes
复制标题
加工假基因的进化方向
DOI：
10.1007/s11427-016-5074-x
复制
发表时间：
2016-08-01
影响因子：
9.1
通讯作者：
Cai, Lu
中科院分区：
文献类型：
--
作者：
Liu, Guoqing;Cui, Xiangjun;Cai, Lu
虽然一些假基因在基因调控中发挥了重要作用，但人们对假基因的功能与进化过程之间的可能关系以及导致假基因进化的力量知之甚少。在这项研究中，我们从进化动力学的角度描述了人类加工的假基因。我们的研究结果表明，假基因趋向于：低GC含量，强二核苷酸偏倚，转录因子结合基序丰度降低，回文短，形成核小体的能力下降。我们探索了形成假基因进化模式的可能的进化力量，并得出结论，假基因的突变可能是由邻居依赖的突变偏差和重组相关选择决定的，至少是部分决定的。
While some pseudogenes have been reported to play important roles in gene regulation, little is known about the possible relationship between pseudogene functions and evolutionary process of pseudogenes, or about the forces responsible for the pseudogene evolution. In this study, we characterized human processed pseudogenes in terms of evolutionary dynamics. Our results show that pseudogenes tend to evolve toward: lower GC content, strong dinucleotide bias, reduced abundance of transcription factor binding motifs and short palindromes, and decreased ability to form nucleosomes. We explored possible evolutionary forces that shaped the evolution pattern of pseudogenes, and concluded that mutations in pseudogenes are likely determined, at least partially, by neighbor-dependent mutational bias and recombination-associated selection.