Dynamics of stability: The physiologic basis of functional health and frailty
Dynamics of stability: The physiologic basis of functional health and frailty
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DOI：
10.1093/gerona/57.3.b115
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发表时间：
2002-03-01
影响因子：
5.1
通讯作者：
Lipsitz, LA
中科院分区：
文献类型：
--
作者：
Lipsitz, LA
在基础休息条件下，大多数健康的生理系统表现出高度不规则的，复杂的动态，代表多个时间尺度上运行的相互作用的调节过程。这些过程使生物体准备好适应性反应。使其准备好并能够对突然的生理压力做出反应。当生物体受到干扰或偏离给定的边界条件时。大多数生理系统引起闭环响应，其在相对短的时间段内操作以使生物体恢复平衡。这会暂时将动态改变为不太复杂的主导响应模式。这被表示为“电抗调谐"。“衰老和疾病与静息动力学复杂性的丧失和对扰动的适应不良反应有关。生理系统动力学的这些改变导致功能衰退和虚弱。量化生理动力学的非线性数学技术可以预测虚弱的发作，旨在恢复健康动力学的干预措施可以防止功能衰退。
Under basal resting conditions most healthy physiologic systems demonstrate highly irregular, complex dynamics that represent interacting regulatory processes operating over multiple time scales. These processes prime the organism for an adaptive response. making it ready and able to react to sudden physiologic stresses. When the organism is perturbed or deviates from a given set of boundary conditions. most physiologic systems evoke closed-loop responses that operate over relatively short periods of time to restore the organism to equilibrium. This transiently alters the dynamics to a less complex, dominant response mode. which is denoted "reactive tuning." Aging and disease are associated with a loss of complexity in resting dynamics and maladaptive responses to perturbations. These alterations in the dynamics of physiologic systems lead to functional decline and frailty. Nonlinear mathematical techniques that quantify physiologic dynamics may predict the onset of frailty, and interventions aimed toward restoring healthy dynamics may prevent functional decline.