Why we should routinely screen Asian American adults for hepatitis B: A cross-sectional study of Asians in California
Why we should routinely screen Asian American adults for hepatitis B: A cross-sectional study of Asians in California
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DOI：
10.1002/hep.21784
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发表时间：
2007-10-01
期刊：
影响因子：
13.5
通讯作者：
So, Samuel K.
中科院分区：
文献类型：
--
作者：
Lin, Steven Y.;Chang, Ellen T.;So, Samuel K.
慢性B型肝炎病毒（HBV）感染是一种严重的肝脏疾病，如果不及时诊断或没有适当的医疗管理，与25%的死于肝硬化或肝癌的机会有关。为了研究亚裔美国人慢性HBV感染和HBV疫苗接种的人口统计学和患病率，我们提供了免费的HBV血清学筛查，并在2001年至2006年期间对旧金山弗朗西斯科湾区的3163名亚裔美国人成年志愿者进行了调查。在接受筛查的患者中，8.9%为慢性HBV感染者。值得注意的是，二分之一至三分之二（65.4%）的慢性感染成年人不知道自己被感染。在那些没有慢性感染的人中，44.8%缺乏针对HBV的保护性抗体，并且可能对未来的感染易感。男性慢性感染的可能性是女性的两倍（12.1%对6.4%）。出生在东亚、东南亚或太平洋岛屿的亚裔美国人慢性感染的可能性是出生在美国的人的19.4倍。自我报告既往接种疫苗对评估HBV保护作用不可靠。在报告接种过疫苗的12%中，5.2%是慢性感染，20.3%缺乏保护性抗体。结论：鉴于亚裔美国人中未被识别的慢性HBV感染的高患病率，我们呼吁医疗保健提供者对亚裔成年人进行HBV常规筛查，无论其疫苗接种状态如何。应向检测呈阳性的人提供文化上适当的信息，以防止疾病传播和适当的医疗管理，以降低他们患肝病的风险。
Chronic hepatitis B virus (HBV) infection is a serious liver disease that, if left undiagnosed or without appropriate medical management, is associated with a 25% chance of death from cirrhosis or liver cancer. To study the demographics and prevalence of chronic HBV infection and HBV vaccination in the Asian American population, we provided free HBV serological screening and administered a survey to 3163 Asian American adult volunteers in the San Francisco Bay Area between 2001 and 2006. Of those screened, 8.9% were chronically infected with HBV. Notably, one-half to two-thirds (65.4%) of the chronically infected adults were unaware that they were infected. Of those who were not chronically infected, 44.8% lacked protective antibodies against HBV and were likely susceptible to future infection. Men were twice as likely as women to be chronically infected (12.1% versus 6.4%). Asian Americans born in East Asia, Southeast Asia, or the Pacific Islands were 19.4 times more likely to be chronically infected than those born in the United States. Self-reporting of prior vaccination was unreliable to assess protection against HBV. Among the 12% who reported having been vaccinated, 5.2% were chronically infected, and 20.3% lacked protective antibodies. Conclusion: Given the high prevalence of unrecognized chronic HBV infection in the Asian American population, we call for healthcare providers to routinely screen Asian adults for HBV, regardless of their vaccination status. Those who test positive should be provided with culturally appropriate information to prevent disease transmission and proper medical management to reduce their risk of liver disease.