Exercise Can Promote Coronary Collateral Development Without Improving Perfusion of Ischemic Myocardium
Exercise Can Promote Coronary Collateral Development Without Improving Perfusion of Ischemic Myocardium
复制标题
运动可以在不改善缺血心肌灌注的情况下促进冠状动脉侧枝发育
DOI：
10.1161/01.cir.60.7.1513
复制
发表时间：
1979
期刊：
影响因子：
37.8
通讯作者：
J. Oxendine
中科院分区：
文献类型：
--
作者：
W. Neill;J. Oxendine
摘要我们研究了运动训练对狗因冠状动脉逐渐闭塞而形成的冠状动脉的影响。冠状动脉左旋支近端闭塞后，33只狗被随机分配到运动组或久坐组。 5周或8周后评估冠状动脉侧支功能。根据来自远端左回旋支的较高逆行血流量和通过侧支循环的较低压降来判断，锻炼过的狗与闭塞的左回旋支建立了更好的心外膜侧支连接。血管造影显示侧支循环没有明显差异。微球数据表明，运动犬并不能更好地防止心动过速引起的由侧支供血的心肌内膜下缺血。
SUMMARYWe studied the effect of exercise training on the coronary collaterals that developed in response to gradual coronary occlusion in dogs. After their proximal left circumflex coronary artery occlusion, 33 dogs were randomly assigned to exercise or sedentary groups. Coronary collateral function was evaluated 5 weeks or 8 weeks later. The exercised dogs developed better epicardial collateral connections to the occluded left circumflex as judged by higher retrograde blood flow from the distal left circumflex and lower pressure drop across the collaterals. No difference in collaterals was apparent angiographically. Microsphere data indicated that exercise dogs were not better protected against tachycardia-provoked subendocardial ischemia in the myocardium supplied by the collaterals.
影响因子：
37.8
作者：
W. Schaper;S. Pasyk
通讯作者：
W. Schaper;S. Pasyk