The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling.
The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling.
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DOI：
10.3389/fmicb.2010.00136
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发表时间：
2010
影响因子：
5.2
通讯作者：
Lavander M
中科院分区：
文献类型：
--
作者：
Bröms JE;Sjöstedt A;Lavander M
土拉菌是一种高毒力的革兰氏阴性细胞内细菌，可引起人畜共患疾病土拉菌病。其毒力的关键是在宿主细胞，特别是单核细胞内繁殖的能力。这种细菌已经发展出复杂的手段来破坏宿主的免疫机制，从而通过阻止吞噬酶体融合，然后逃逸到细胞质中，从而促进其细胞内生存，并在细胞质中繁殖。此外，它靶向和操纵许多宿主细胞信号通路，从而改善其他杀菌能力。许多潜在的分子机制尚不清楚，但直接或间接负责上述许多机制的关键因素依赖于Francisella致病岛（FPI）编码蛋白的表达，这表明构成了VI型分泌系统。我们在这里描述了目前关于FPI组成部分的知识以及它们所扮演的角色。
Francisella tularensis is a highly virulent gram-negative intracellular bacterium that causes the zoonotic disease tularemia. Essential for its virulence is the ability to multiply within host cells, in particular monocytic cells. The bacterium has developed intricate means to subvert host immune mechanisms and thereby facilitate its intracellular survival by preventing phagolysosomal fusion followed by escape into the cytosol, where it multiplies. Moreover, it targets and manipulates numerous host cell signaling pathways, thereby ameliorating the otherwise bactericidal capacity. Many of the underlying molecular mechanisms still remain unknown but key elements, directly or indirectly responsible for many of the aforementioned mechanisms, rely on the expression of proteins encoded by the Francisella pathogenicity island (FPI), suggested to constitute a type VI secretion system. We here describe the current knowledge regarding the components of the FPI and the roles that have been ascribed to them.
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