ChenPhos: Highly Modular P-Stereogenic C1-Symmetric Diphosphine Ligands for the Efficient Asymmetric Hydrogenation of α-Substituted Cinnamic Acids
ChenPhos: Highly Modular P-Stereogenic C1-Symmetric Diphosphine Ligands for the Efficient Asymmetric Hydrogenation of α-Substituted Cinnamic Acids
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DOI：
10.1002/anie.201304472
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发表时间：
2013-08-12
影响因子：
16.6
通讯作者：
Nettekoven, Ulrike
中科院分区：
文献类型：
--
作者：
Chen, Weiping;Spindler, Felix;Nettekoven, Ulrike
这些猫是purrfectionists：ChenPhos配体（参见结构）在标题反应中显示出比其具有两个二甲基氨基乙基取代的二茂铁基（苯基）膦基的C2-对称前体显著更高的催化活性。这些配体的易接近性、极端的空气稳定性和高的对映选择性、活性和生产率使它们非常有希望用于广泛的实际应用。
These cats are purrfectionists: The ChenPhos ligands (see structure) showed dramatically higher catalytic activity in the title reaction than their C2‐symmetric predecessor with two dimethylaminoethyl‐substituted ferrocenyl (phenyl) phosphanyl groups. The ready accessibility, extreme air stability, and high enantioselectivity, activity, and productivity of these ligands make them very promising for a wide range of practical applications.