The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy
The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy
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DOI：
10.1016/j.jri.2007.04.007
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发表时间：
2008-01-01
影响因子：
3.4
通讯作者：
Shiozaki, Arihiro
中科院分区：
文献类型：
--
作者：
Shigeru, Saito;Akitoshi, Nakashima;Shiozaki, Arihiro
NK细胞杀死肿瘤细胞和病毒感染细胞，并分泌多种细胞因子。这些效应功能受活化受体信号和抑制性受体信号之间的平衡调节，这些信号由特定的主要组织相容性复合体（MHC）或非MHC配体触发。目前认为，T细胞免疫中免疫刺激和免疫调节之间的平衡是通过Th1/Th2/Th3/Tr1和CD4(+)CD25（+）调节性T （Treg）细胞模式实现的。在这里，我们讨论NK细胞在人类妊娠中的细胞因子模式。在正常、完整妊娠期间，外周血NKr1细胞和蜕膜NK3细胞数量增加，而这些NK细胞数量在流产病例中显著减少，提示NK1/NK2/NK3/NKr1失衡与流产有关。最近的研究表明，除了Treg细胞外，调节性NK细胞（NK reg）在维持妊娠中也起着非常重要的作用。本文综述了近年来NK reg细胞的研究进展，重点介绍了NK reg细胞和细胞毒性NK细胞对生殖免疫反应的影响。2007爱思唯尔爱尔兰有限公司版权所有。
NK cells kill tumor cells and virus-infected cells as well as secrete a variety of cytokines. These effector functions are regulated by the balance between activating receptor signals and inhibitory receptor signals which are triggered by specific major histocompatibility complex (MHC) or non-MHC ligands. It is thought currently that the balance between inummostimulation and immunoregulation in T cell immunity is achieved by a Th1/Th2/Th3/Tr1 and CD4(+)CD25(+) regulatory T (Treg) cell paradigm. Here, we discuss the cytokine paradigm of NK cells in human pregnancy. During normal, intact pregnancy, peripheral blood NKr1 cells and decidual NK3 cells increase, while these NK cell populations decrease significantly in miscarriage cases, suggesting that an imbalance in NK1/NK2/NK3/NKr1 is correlated with miscarriage. Recent investigations have shown that not only Treg cells, but also regulatory NK (NK reg) cells, play very important roles in the maintenance of pregnancy. We summarize the progress in studying NK reg cells and focus on how NK reg cells and cytotoxic NK cells affect the reproductive immune response. (c) 2007 Elsevier Ireland Ltd. All rights reserved.