[A new embolic material: super absorbent polymer (SAP) microsphere and its embolic effects].
[A new embolic material: super absorbent polymer (SAP) microsphere and its embolic effects].
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新型栓塞材料：高吸水性聚合物（SAP）微球及其栓塞作用
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
H. Nakamura
中科院分区：
文献类型：
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作者：
Y. Jiaqi;S. Hori;K. Minamitani;T. Hashimoto;H. Yoshimura;N. Nomura;T. Ishida;H. Fukuda;K. Tomoda;H. Nakamura
SAP微球（丙烯酸钠-乙烯醇共聚物）具有在几分钟内吸收液体并增加其直径的能力。其直径也可以校准。离子型造影剂和人血清中的直径分别比原始尺寸大2.1和3.5倍。它可以通过带有离子造影剂的微导管，并在闭塞点膨胀到所需的尺寸。由于其对造影剂的吸收，可在荧光透视下识别。共10只兔肾栓塞，然后在1-14周内切除。所有病例均无再通。肾周组织未见粘附，1周时内皮细胞反应性改变有限。在研究期间的任何时间均未发现平滑肌层变化。一周内，在血管周围组织中发现有限的中性粒细胞浸润。SAP-微球在14周期间保持其球形。4周后出现广泛的纤维化和钙化。SAP微球作为栓塞剂有望获得满意的栓塞治疗效果。
SAP-Microsphere (sodium acrylic acid-vinyl alcohol copolymer) has the ability to absorb fluids within a few minutes and increase its diameter. Its diameter can also be calibrated. The diameters in ionic contrast material and human serum are 2.1 and 3.5 times larger, respectively, than the original size. It can pass through a microcatheter with an ionic contrast material, and swells at the occluding point into the desired size. It can be recognized under fluoroscopy due to its absorption of contrast material. A total of 10 rabbit kidney embolizations were done followed by resection in 1-14 weeks. Recanalization was absent in all cases. No adhesion to the perirenal tissue was found. Limited reactive change in endothelial cells was found at one week. No changes in the smooth muscle layer were found at any time during the study. Limited infiltration of neutrophil cells was found in perivascular tissue within a period of one week. SAP-Microspheres maintained their spherical shape during a 14-week period. Extensive fibrosis and calcification were found after 4 weeks. SAP-Microspheres are promising as an embolic agent to obtain satisfactory results of embolization therapy.