Probabilistic classification and gambling in patients with schizophrenia receiving medication: comparison of risperidone, olanzapine, clozapine and typical antipsychotics
Probabilistic classification and gambling in patients with schizophrenia receiving medication: comparison of risperidone, olanzapine, clozapine and typical antipsychotics
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接受药物治疗的精神分裂症患者的概率分类和赌博：利培酮、奥氮平、氯氮平和典型抗精神病药物的比较
DOI：
10.1007/s00213-011-2634-4
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发表时间：
2012
影响因子：
3.4
通讯作者：
R. Beninger
中科院分区：
文献类型：
--
作者：
James I. Wasserman;R. J. Barry;L. Bradford;N. Delva;R. Beninger
理性我们之前已经证明，接受典型抗精神病药物治疗的精神分裂症患者在依赖纹状体功能的天气预测概率分类学习(PCL)任务中受到损害，而接受非典型抗精神病药物治疗的类似患者在爱荷华州赌博任务(IGT)依赖于内侧前额叶皮质功能时受到损害。目的我们验证了一种假设，即接受利培酮治疗的患者的测试表现将更接近于接受典型抗精神病药物治疗的患者。结果服用利培酮、奥氮平、氯氮平或典型抗精神病药物的精神分裂症患者组在阳性和阴性症状量表或迷你精神状态检查(MSE)上没有差异，但在MMSE上的得分低于对照组。在PCL任务中，接受氯氮平治疗的患者在试验中有所改善，而接受典型抗精神病药物、奥氮平或利培酮治疗的患者没有改善。对于IGT，接受典型抗精神病药物或利培酮治疗的患者在试验中有所改善，而接受氯氮平或奥氮平治疗的患者没有改善。结论结果普遍支持这样的假设，即接受利培酮治疗的患者比接受其他非典型抗精神病药物治疗的患者表现更接近于接受典型抗精神病药物治疗的患者。
RationaleWe have previously shown that patients with schizophrenia treated with typical antipsychotics were impaired on the weather prediction probabilistic classification learning (PCL) task that relies on striatal function, and that similar patients treated with atypical antipsychotics were impaired on the Iowa gambling task (IGT) that depends on medial prefrontocortical function.ObjectivesWe tested the hypothesis that test performance of patients treated with risperidone will be more similar to those treated with typical rather than atypical antipsychotics.ResultsGroups of schizophrenia patients treated with risperidone, olanzapine, clozapine or typical antipsychotics did not differ on the Positive and Negative Syndrome Scale or the Mini Mental State Exam (MMSE) but scored lower than controls on the MMSE. For the PCL task, patients treated with clozapine improved over trials while those treated with typical antipsychotics, olanzapine, or risperidone did not. For the IGT, patients treated with typical antipsychotics or risperidone improved over trials while those treated with clozapine or olanzapine did not.ConclusionsResults generally supported the hypothesis that patients treated with risperidone perform more like those treated with typical antipsychotics than those treated with other atypical antipsychotics.
影响因子：
17.7
作者：
Bilder, RM;Goldman, RS;Lieberman, JA
通讯作者：
Lieberman, JA
影响因子：
14.5
作者：
Bechara, A;Tranel, D;Damasio, H
通讯作者：
Damasio, H