SHORT-CHAIN FATTY-ACIDS STIMULATE ILEAL MOTILITY IN HUMANS
SHORT-CHAIN FATTY-ACIDS STIMULATE ILEAL MOTILITY IN HUMANS
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DOI：
10.1016/s0016-5085(88)80068-4
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发表时间：
1988-12-01
期刊：
影响因子：
29.4
通讯作者：
ZINSMEISTER, AR
中科院分区：
文献类型：
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作者：
KAMATH, PS;PHILLIPS, SF;ZINSMEISTER, AR
我们检验了短链脂肪酸（SCFAs）和扩张会刺激人类回肠运动的假设。在18名健康志愿者中，在滴入SCFA、空气和盐水的推注后，记录回结肠区域的管腔内压力。回肠运动刺激更经常SCFAs比类似体积的空气或盐水。虽然膨胀体积的增加引起更多的收缩，这种现象是不明显的重复刺激后，这表明在人回肠的“mechanoreceptor”有一个不应期。腹痛、痉挛和排便冲动的症状可能由SCFA滴注引起，即使是少量。SCFAs刺激回肠的运动与胃肠调节肽的全身释放无关，也不受纳洛酮或吲哚美辛的影响。短链脂肪酸可被视为结肠内容物的“标记物”，可能与人类结肠回肠反流的运动反应有关。
We tested the hypothesis that short-chain fatty acids (SCFAs) and distention would stimulate ileal motility in humans. Intraluminal pressures in the ileocolonic reigon were recorded in 18 healthy human volunteers after instillation of boluses of SCFAs, air, and saline. Ileal motility was stimulated more often by SCFAs than by similar volumes of air or saline. Although increasing volumes of distention evoked greater numbers of contractions, this phenomenon was not apparent after repeated stimulation, suggesting that the "mechanoreceptor" in the human ileum has a refractory period. Symptoms of abdominal pain, cramps, and an urge to defecate may have resulted from instillation of SCFAs, even at small volumes. The motility stimulated in the ileum by SCFAs was not associated with systemic release of gastrointestinal regulatory peptides and was not affected by naloxone or indomethacin. Short-chain fatty acids, which can be considered as "markers" of colonic contents, might be associated with the motor response to coloileal reflux in humans.