Shared and specific functional connectivity alterations in unmedicated bipolar and major depressive disorders based on the triple-network model
Shared and specific functional connectivity alterations in unmedicated bipolar and major depressive disorders based on the triple-network model
复制标题
基于三网络模型的非药物双相情感障碍和重度抑郁症的共享和特定功能连接改变
DOI：
10.1007/s11682-018-9978-x
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Ruiwang Huang
中科院分区：
文献类型：
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作者：
Junjing Wang;Ying Wang;Xia Wu;Huiyuan Huang;Yanbin Jia;Shuming Zhong;Xiaoyan Wu;Lianping Zhao;Yuan He;Li Huang;Ruiwang Huang
双相情感障碍（BD）在临床实践中经常被误诊为重性抑郁障碍（MDD），尤其是在抑郁发作时。一个统一的三重网络模型，包括默认模式网络（DMN），中央执行网络（CEN）和显着性网络（SN），已被提出来解释精神和神经疾病的神经病理生理。尽管一些研究揭示了BD和MDD在DMN、CEN和SN的关键区域中的共享和特定改变，并且一些研究使用不同的措施来检测BD和MDD的三重网络中的详细改变，但它们在三重网络中改变的功能连接（FC）的共享和特定模式仍不清楚。在这项研究中，我们获取了38名未用药的BD患者和35名未用药的MDD患者在抑郁发作期间的静息状态fMRI（R-fMRI）数据，以及47名健康对照者的数据。沿着。我们首先通过使用独立成分分析（伊卡）确定DMN，SN和CEN的空间独立成分，然后我们估计每组的ROI间和网络间FC。结果表明：（1）与正常对照组相比，BD组和MDD组DMN内左侧mPFC和右侧楔前叶的网络内FC均较弱，左侧AI和右侧AI的ROI间FC均较弱;（2）与健康对照组相比，BD组rCEN内右侧dlPFC的网络内FC较弱，MDD组较强，右侧dlPFC与右侧ANG之间的ROI间FC较强;（3）与MDD组和对照组相比，BD组的左PPC和右AI之间的ROI间FC以及lCEN和SN之间的网络间FC更强。本研究为进一步了解抑郁症患者的神经病理生理和临床症状提供了新的信息。
Bipolar disorder (BD) is frequently misdiagnosed as major depressive disorder (MDD) in clinical practice, especially during depressive episodes. A unifying triple-network model, involving the default mode network (DMN), central executive network (CEN) and salience network (SN), has been proposed to explain the neural physiopathology of psychiatric and neurological disorders. Although several studies revealed shared and specific alterations between BD and MDD in key regions of DMN, CEN, and SN, and a few studies used different measures to detect detailed alterations in the triple networks in BD and MDD, their shared and specific patterns of altered functional connectivity (FC) in the triple networks has remained unclear. In this study, we acquired resting-state fMRI (R-fMRI) data from 38 unmedicated BD and 35 unmedicated MDD patients during depressive episodes along with 47 healthy controls. We first determined the spatially independent components of the DMN, SN, and CEN by using independent component analysis (ICA); then we estimated the inter-ROI and inter-network FC for each group. By comparing the differences between the three groups, we obtained the following results: (1) both the BD and MDD patients showed shared weaker intra-network FC in the left mPFC and right precuneus within the DMN as well as weaker inter-ROI FC between the left AI and right AI compared with the healthy controls; (2) the BD had weaker while the MDD had stronger intra-network FC in the right dlPFC within the rCEN as well as stronger inter-ROI FC between the right dlPFC and right ANG compared with the healthy controls; (3) the BD showed specific, stronger inter-ROI FC between the left PPC and right AI as well as stronger inter-network FC between the lCEN and SN compared with either the MDD or the control group. Our findings provide new information for understanding the neural physiopathology and clinical symptoms of depressed BD and MDD patients.