Frontal dysfunction during a cognitive task in drug-naive patients with panic disorder as investigated by multi-channel near-infrared spectroscopy imaging
Frontal dysfunction during a cognitive task in drug-naive patients with panic disorder as investigated by multi-channel near-infrared spectroscopy imaging
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DOI：
10.1016/j.neures.2007.05.016
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发表时间：
2007-09-01
影响因子：
2.9
通讯作者：
Okazaki, Yuji
中科院分区：
文献类型：
--
作者：
Nishimura, Yukika;Tanii, Hisashi;Okazaki, Yuji
本研究通过使用多通道近红外光谱 (NIRS)，调查了 5 名患有或不患有广场恐惧症的惊恐障碍初治患者和 33 名年龄、性别和任务表现匹配的健康志愿者在执行单词流利性任务期间的含氧 ([oxy-Hb]) 和脱氧 ([deoxy-Hbl) 血红蛋白浓度变化。惊恐障碍患者执行任务期间左下额叶 [oxy-Hb] 的变化明显小于健康对照者。这项初步研究表明，恐慌症患者的认知功能所需的左额叶可能受损。 (C) 2007 Elsevier Ireland Ltd 和日本神经科学学会。版权所有。
The present study investigated oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hbl) hemoglobin concentration changes during the performance of a word fluency task in the frontal region of five drug-naive patients with panic disorder with or without agoraphobia and in 33 age-, sex-, and task performance-matched healthy volunteers by using multi-channel near-infrared spectroscopy (NIRS). The left inferior frontal [oxy-Hb] changes during performance of the task in patients with panic disorder were significantly smaller than those of healthy controls. This pilot study suggests the possibility that the left frontal lobe, required for cognitive function, is impaired in patients with panic disorder. (C) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.