Exposure to indoor allergens in day-care facilities: Results from 2 North Carolina counties
Exposure to indoor allergens in day-care facilities: Results from 2 North Carolina counties
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DOI：
10.1016/j.jaci.2005.04.022
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发表时间：
2005-07-01
影响因子：
14.2
通讯作者：
Zeldin, DC
中科院分区：
文献类型：
--
作者：
Arbes, SJ;Sever, M;Zeldin, DC
背景资料：63%的美国5岁以下儿童在正规的儿童保育机构，日托设施可能是暴露于室内过敏原的重要来源。目的：本研究检测了北卡罗来纳州2个县89个日托设施中7种室内过敏原的水平。在每一个设施，管理一份问卷，进行观察，从一个房间的地毯和非地毯区域收集真空灰尘样品。过敏原浓度测定抗体为基础的ELISAs.Results：每种过敏原检测到大多数设施（52%至100%）。Alternaria alternata的几何平均浓度为5.19 μ g/g，Can f 1为2.06 μ g/g，Fel d 1为1.43 μ g/g，Bla g 1为0.21 U/g，Der p 1为0.20 μ g/g，Der f 1为0.10 μ g/g，Mus m 1为0.01 μ g/g。7种过敏原中有5种的浓度与全国房屋中铅和过敏原调查中美国南部家庭抽样的浓度没有统计学差异。在房间里的地毯和硬表面地板，水平的交替，可以f 1，德f 1，德p 1，和Fel d 1在统计学上更高的carped.Conclusions：在这项调查中的日托设施在北卡罗来纳州，室内过敏原的可检测水平普遍found.For许多年幼的儿童和日托工作人员，日托设施可能是一个来源的临床相关暴露于室内过敏原。
Background: With 63% of US children under 5 years of age in regular child care, day-care facilities could be an important source of exposure to indoor allergens.Objective: This study examined levels of 7 indoor allergens in 89 day-care facilities in 2 North Carolina counties.Methods: At each facility, a questionnaire was administered, observations were made, and vacuumed dust samples were collected from carpeted and noncarpeted areas of one room. Allergen concentrations were measured with antibody-based ELISAs.Results: Each allergen was detected in a majority of facilities (52% to 100%). Geometric mean concentrations were 5.19 mu g/g for Alternaria alternata, 2.06 mu g/g for Can f 1, 1.43 mu g/g for Fel d 1, 0.21 U/g for Bla g 1, 0.20 mu g/g for Der p 1, 0.10 mu g/g for Der f 1, and 0.01 mu g/g for Mus m 1. Concentrations for 5 of the 7 allergens were not statistically different from concentrations found in southern US homes sampled in the National Survey of Lead and Allergens in Housing. In rooms with carpet and hard-surfaced flooring, levels of A alternata, Can f 1, Der f 1, Der p 1, and Fel d 1 were statistically higher on carpet.Conclusions: In this survey of day-care facilities in North Carolina, detectable levels of indoor allergens were commonly found. For many young children and day-care staff, day-care facilities might be a source of clinically relevant exposures to indoor allergens.