Preparation Fe3O4@chitosan-graphene quantum dots nanocomposites for fluorescence and magnetic resonance imaging
Preparation Fe3O4@chitosan-graphene quantum dots nanocomposites for fluorescence and magnetic resonance imaging
复制标题
用于荧光和磁共振成像的Fe3O(4)@壳聚糖-石墨烯量子点纳米复合材料的制备
DOI：
10.1016/j.cplett.2021.139060
复制
发表时间：
2021-09-22
影响因子：
2.8
通讯作者：
Jiang, Yong
中科院分区：
文献类型：
--
作者：
Wang, Kai;Xu, Xiaoguang;Jiang, Yong
最近开发的具有多种生物分子检测功能的纳米探针在各种生物医学成像应用中引起了人们的极大兴趣。在此，我们设计并制备了用于荧光和磁共振成像（MRI）的Fe3O4@壳聚糖-石墨烯量子点（Fe3O4@CS-GQDs）纳米复合材料。 Fe3O4@CS-GQDs纳米复合材料的光致发光光谱在330 nm紫外激发光下在434 nm处呈现出发射峰。 Fe3O4@CS-GQD纳米复合材料在水溶液中表现出优异的MRI结果。 Fe3O4@CS-GQDs 纳米复合材料的细胞毒性在 Hela 细胞中观察到较低的细胞毒性。基于这些结果，Fe3O4@CS-GQDs 纳米复合材料被证实是有前途的用于肿瘤检测的荧光和 MRI 成像造影剂。
The recent development of nanoprobes with multiple biomolecular detection functionalities have attracted considerable interests in various biomedical imaging applications. Herein, we have designed and prepared Fe3O4@chitosan-graphene quantum dots (Fe3O4@CS-GQDs) nanocomposites for fluorescence and magnetic resonance imaging (MRI). The photoluminescent spectra of Fe3O4@CS-GQDs nanocomposites exhibit an emission peak at 434 nm under the ultraviolet excitation light of 330 nm. Fe3O4@CS-GQD nanocomposites show the excellent MRI results in aqueous solution. The cytotoxicity of Fe3O4@CS-GQDs nanocomposites is observed low cytotoxicity in Hela cells. Based on the results, Fe3O4@CS-GQDs nanocomposites are confirmed as promising fluorescence and MRI imaging contrast agents for tumor detection.