Early pregnancy soluble E-selectin concentrations and risk of preeclampsia
Early pregnancy soluble E-selectin concentrations and risk of preeclampsia
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DOI：
10.1097/hjh.0b013e328352573b
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发表时间：
2012-05-01
影响因子：
4.9
通讯作者：
Delles, Christian
中科院分区：
文献类型：
--
作者：
Carty, David M.;Anderson, Lesley A.;Delles, Christian
目的：妊娠晚期子痫前期妇女内皮功能障碍和炎症循环生物标志物升高。我们检测了妊娠早期血浆中炎症细胞因子和粘附分子的水平，以评估它们预测子痫前期的能力。方法：在一项前瞻性纵向研究中，招募了2600名在妊娠12-16周到产前医院（预约）就诊的单胎妊娠且无高血压史的妇女。其中，49名（1.9%）发生了子痫前期，而74名年龄和体重指数相匹配的无并发症妊娠妇女被选为对照组。在妊娠16周和28周（11例，39例对照）和产后（6例，36例对照）再次对具有先兆子痫危险因素的妇女进行抽样。结果：从多重分析来看，可溶性e -选择素浓度在12-16周时更高，随后发生子痫前期的妇女（15.1 +/- 4.9 vs 12.9 +/- 4.5 ng/ml， P=0.02）。在妊娠第28周，e -选择素浓度在发生子痫前期的妇女中再次高于对照组（14.4 +/- 5.6 vs 10.7 +/- 3.5 ng/ml， P=0.010），而在产后样本中，两组之间的水平没有差异。结论：妊娠早期可溶性e -选择素浓度的变化可能反映了潜在的病理生理过程，可能为子痫前期提供机制见解。
Objective: Circulating biomarkers of endothelial dysfunction and inflammation are elevated in late pregnancy in women with preeclampsia. We examined plasma levels of inflammatory cytokines and adhesion molecules in early pregnancy, to assess their ability to predict preeclampsia.Methods: In a prospective longitudinal study, 2600 women with singleton pregnancies and no history of hypertension were recruited at their antenatal hospital (booking) visit at gestational week 12-16. Of these, 49 (1.9%) developed preeclampsia, whereas 74 women matched for age and BMI with uncomplicated pregnancies were selected as controls. A subset of women with risk factors for preeclampsia were sampled again at gestational weeks 16 and 28 (11 cases, 39 controls) and postnatally (six cases, 36 controls).Results: From multiplex analysis, soluble E-selectin concentrations were higher at 12-16 weeks in women who subsequently developed preeclampsia (15.1 +/- 4.9 versus 12.9 +/- 4.5 ng/ml, P=0.02). At gestational week 28, E-selectin concentrations were again higher in women who went on to develop preeclampsia compared with controls (14.4 +/- 5.6 versus 10.7 +/- 3.5 ng/ml, P=0.010), whereas levels were not different between the two groups in postpartum samples.Conclusion: Changes in soluble E-selectin concentration in early pregnancy may reflect underlying pathophysiological processes, potentially providing mechanistic insights into preeclampsia.