Synthesis, structure and superoxide dismutase-like activity of two mixed-ligand Cu(II) complexes with N,N′-bis(2-pyridylmethyl)amantadine
Synthesis, structure and superoxide dismutase-like activity of two mixed-ligand Cu(II) complexes with N,N′-bis(2-pyridylmethyl)amantadine
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DOI：
10.1016/j.poly.2016.07.027
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发表时间：
2016-10
期刊：
影响因子：
2.6
通讯作者：
Ying-Hua Zhou;Xian-Wen Liu;Li-Qing Chen;Suqin Wang;Yong Cheng
中科院分区：
文献类型：
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作者：
Ying-Hua Zhou;Xian-Wen Liu;Li-Qing Chen;Suqin Wang;Yong Cheng
合成了两个混配Cu（II）配合物[Cu（L1）（L2）]（ClO 4）2·H2O（1）和[Cu（L1）（L3）]（ClO 4）2·H2O·CH 3OH（2）（L1=N，N′-双（2-吡啶甲基）金刚烷胺，L2= 5，5 ′-二甲基-2，2 ′-联吡啶，L3= 1，10-邻菲咯啉），并通过元素分析、紫外-可见光谱、红外光谱和单晶X射线衍射对其进行了表征。1和2中的铜离子表现出由CuN 5配位提供的轻微扭曲的四棱锥构型。用循环伏安法测定了两种配合物均呈现准可逆的Cu（II）/Cu（I）单电子氧化还原波。在LanL 2DZ基组上，采用密度泛函B3 LYP方法计算了前线分子轨道能量.在pH7.8条件下，用NBT法测得1和2的超氧化物歧化酶（SOD）样活性（IC_（50））分别为0.167和0.242 μM。两种配合物的SOD活性的差异可以归因于辅助配体的刚性。
Two mixed-ligand Cu(II) complexes, [Cu(L1)(L2)](ClO4)2·H2O (1) and [Cu(L1)(L3)](ClO4)2·H2O·CH3OH (2) (L1=N,N′-bis(2-pyridylmethyl)amantadine, L2= 5,5′-dimethy-2,2′-bipyridine, and L3= 1,10-phenanthroline), were synthesized and characterized by elemental analysis, UV–Vis, infrared spectra and single crystal X-ray diffraction. Copper ions in1and2behave the slightly distorted tetragonal pyramid configuration provided by CuN5 coordination set. Both complexes exhibit thequasi-reversible Cu(II)/Cu(I) one-electron redox waves determined by the cyclic voltammetry. Moreover, the frontier molecular orbital energies were obtained by DFT calculations with B3LYP method at LanL2DZ basis. Furthermore, by using NBT assay at pH 7.8, the superoxide dismutase (SOD)-like activity (IC50) of1and2were measured to be 0.167 and 0.242 μM, respectively. The difference in SOD-like activities of two complexes could be ascribed to the rigidity of the auxiliary ligands.