EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss
EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss
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DOI：
10.1152/ajpregu.1999.277.3.r640
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发表时间：
1999-09-01
影响因子：
2.8
通讯作者：
Dijk, DJ
中科院分区：
文献类型：
--
作者：
Cajochen, C;Khalsa, SBS;Dijk, DJ
本研究的目的是量化慢眼动（SEM），眨眼率，清醒脑电图（EEG）功率密度，神经行为表现，和血浆褪黑激素的昼夜节律之间的关联在一个队列的10名健康男性在长达32小时的持续觉醒。神经行为表现的时间过程的特点是相当稳定的水平，在整个第一个16小时的觉醒，然后恶化的褪黑激素分泌的阶段。这种恶化与SEM的增加密切相关。额叶低频EEG活动（1-7 Hz）表现出显着增加与清醒时间和昼夜节律调制。EEG α活动表现出昼夜节律调节。SEM和EEG活动的动态被锁定在神经行为表现的变化，并滞后于血浆褪黑激素的节奏。数据表明，大脑的额叶区域比枕叶区域更容易受到睡眠不足的影响。额叶EEG活动和眼部参数可用于监测和预测与睡眠丧失和昼夜节律失调相关的神经行为表现的变化。
The aim of this study was to quantify the associations between slow eye movements (SEMs), eye blink rate, waking electroencephalogram (EEG) power density, neurobehavioral performance, and the circadian rhythm of plasma melatonin in a cohort of 10 healthy men during up to 32 h of sustained wakefulness. The time course of neurobehavioral performance was characterized by fairly stable levels throughout the first 16 h of wakefulness followed by deterioration during the phase of melatonin secretion. This deterioration was closely associated with an increase in SEMs. Frontal low-frequency EEG activity (1-7 Hz) exhibited a prominent increase with time awake and little circadian modulation. EEG alpha activity exhibited circadian modulation. The dynamics of SEMs and EEG activity were phase locked to changes in neurobehavioral performance and lagged the plasma melatonin rhythm. The data indicate that frontal areas of the brain are more susceptible to sleep loss than occipital areas. Frontal EEG activity and ocular parameters may be used to monitor and predict changes in neurobehavioral performance associated with sleep loss and circadian misalignment.