Community identification of natural health product-drug interactions
Community identification of natural health product-drug interactions
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DOI：
10.1345/aph.1h463
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发表时间：
2007-07-01
影响因子：
2.9
通讯作者：
Vohra, Sunita
中科院分区：
文献类型：
--
作者：
Charrois, Theresa L.;Hill, Richard L.;Vohra, Sunita
背景：大多数加拿大人使用天然保健品（NHP），其中大部分是在药店购买的。社区药剂师定期对 NHP 进行实地询问。因此，药剂师非常适合回答有关 NHP 使用以及与其他药物相互作用的问题。 目的：确定社区药剂师对 NHP 和 NHP 相关不良事件 (AE) 的熟悉程度，以及他们就潜在和已知的 NHP 与药物相互作用提供咨询的知识和能力。 方法：调查问题源自对先前调查的文献综述、从加拿大卫生部收集的数据，并与临床医生、药剂师、政策制定者和研究人员协商。阿尔伯塔省和不列颠哥伦比亚省 321 名社区药剂师的方便样本被要求参与。结果：我们收到了 132 名药剂师的答复，答复率为 41% (132/321)。总共 19% 的样本此前曾向加拿大卫生部报告过不良事件。当具体询问 NHP 与药物相互作用/不良事件时，47% 的药剂师表示他们已经发现了潜在的相互作用；然而，其中只有 2 家向加拿大卫生部报告了这一情况。药剂师最熟悉（76% 的受访者）舍曲林和圣约翰草之间的相互作用，而最不熟悉 NHP 和抗逆转录病毒药物之间的相互作用。 结论：这项调查提供的证据表明，药剂师遇到了可报告的 NHP 与药物相互作用，但很少选择报告这些事件。目前缺乏有关 NHP AE 的可用数据，因此很难为患者和医疗保健提供者提供管理 AE 和药物相互作用的有用策略。需要改变当前由 NHP 引起的 AE 监测系统，并需要对医疗保健专业人员进行有关 NHP 与药物相互作用的进一步教育。
BACKGROUND: The majority of Canadians use natural health products (NHPs), most of which are purchased in pharmacies. Community pharmacists regularly field inquiries regarding NHPs. As such, pharmacists are ideally placed to answer questions about NHP use and interactions with other medications.OBJECTIVE: To identify community pharmacists' familiarity with NHPs and NHP-related adverse events (AEs) and their knowledge and ability to counsel on potential and known NHP-drug interactions.METHODS: Survey questions were derived from a literature review of previous surveys, data collected from Health Canada, and in consultation with clinicians, pharmacists, policy-makers, and researchers. A convenience sample of 321 community pharmacists in Alberta and British Columbia were asked to participate.RESULTS: We received responses from 132 pharmacists, resulting in a response rate of 41% (132/321). A total of 19% of the sample had previously reported an adverse event to Health Canada. When asked specifically about NHP-drug interactions/AEs, 47% of pharmacists stated that they had identified a potential interaction; however, only 2 of these reported it to Health Canada. Pharmacists were most familiar (76% of respondents) with the interaction between sertraline and St. John's wort and were least familiar with interactions between NHPs and anti-retrovirals.CONCLUSIONS: This survey provides evidence to suggest that pharmacists encounter reportable NHP-drug interactions, yet rarely choose to report these events. The current lack of available data on NHP AEs makes it difficult to provide patients and healthcare providers with useful strategies for managing AEs and drug interactions. Changes to the current system of monitoring AEs due to NHPs and further education of healthcare professionals regarding NHP-drug interactions is required.