Longitudinal assessment of NREM sleep EEG in typically developing and medication-free ADHD adolescents: first year results
Longitudinal assessment of NREM sleep EEG in typically developing and medication-free ADHD adolescents: first year results
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DOI：
10.1016/j.sleep.2021.01.052
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发表时间：
2021-02-15
期刊：
影响因子：
4.8
通讯作者：
Feinberg, Irwin
中科院分区：
文献类型：
--
作者：
Darchia, Nato;Campbell, Ian Glenn;Feinberg, Irwin
目的：临床观察和结构MRI研究提示，脑成熟延迟是引起注意缺陷多动障碍（ADHD）的主要原因。睡眠脑电图（EEG）显示了青春期的主要变化，为研究成熟延迟的脑电生理学证据提供了机会。我们提供了一项正在进行的睡眠脑电图纵向研究的数据，这些数据来自于无药物多动症和典型发育中的青少年，以调查这种成熟延迟的脑电生理证据。方法：招募9名诊断为ADHD的青少年（综合表现，DSM-V标准，平均年龄12.39 +/- 0.61岁，2名女性）和9名典型发展对照组（12.08 +/- 0.35岁，4名女性）。受试者每年在实验室进行两次适应夜间和整夜多导睡眠描记术。结果：ADHD组和对照组的基本睡眠结构没有差异。此外，我们发现在delta功率上没有组间差异（p = 0.77），但发现ADHD组可能有更高theta功率的趋势（p = 0.057）。在4个非快速眼动（NREM）阶段，标准化δ功率的下降在各组之间存在差异（p < 0.05），其中ADHD组在第一个非快速眼动（NREM）阶段的δ功率百分比较低。结论：我们的数据支持基本睡眠结构未因ADHD而改变的主要证据。我们的数据确实表明ADHD患者的睡眠稳态恢复过程发生了改变。前两次记录的θ波结果提示与ADHD相关的成熟延迟，但需要后续数据点。(C) 2021 Elsevier B.V.版权所有
Objective: Clinical observation and structural MRI studies suggest that delayed brain maturation is a major cause of attention deficit hyperactivity disorder (ADHD). Sleep electroencephalogram (EEG) which exhibits major changes across adolescence provides an opportunity to investigate brain electrophysiology evidence for maturational delay. We present data from an ongoing longitudinal study of sleep EEG in medication-free ADHD and typically developing adolescents to investigate brain electrophysiological evidence for this maturational delay.Methods: Nine adolescents diagnosed with ADHD (combined presentation, DSM-V criteria, mean age 12.39 +/- 0.61 years, 2 females), and nine typically developing controls (12.08 +/- 0.35 years, 4 females) were recruited. Subjects underwent an adaptation night and all night polysomnography twice yearly at the Laboratory.Results: Basic sleep structure did not differ between the ADHD and control groups. In addition, we found no group differences on delta power (p = 0.77), but found a possible trend toward higher theta power (p = 0.057) for the ADHD group. The decline of standardized delta power across the 4 non-rapid eye movement (NREM) periods differed by group (p < 0.05) with the percent delta power in the first NREM period being lower in the ADHD group.Conclusions: Our data support the preponderant evidence that basic sleep structure is unaltered with ADHD. Our data do suggest altered sleep homeostatic recuperative processes in ADHD. The theta findings from the first two recordings are suggestive of a maturational delay associated with ADHD, but follow-up data-points are needed. (C) 2021 Elsevier B.V. All rights reserved.