Biodegradable Magnesium Alloys Developed as Bone Repair Materials: A Review.
Biodegradable Magnesium Alloys Developed as Bone Repair Materials: A Review.
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作为骨修复材料开发的可生物降解镁合金：综述
作者：
Liu C;Ren Z;Xu Y;Pang S;Zhao X;Zhao Y
骨修复材料作为修复人体骨缺损和替代硬组织的重要手段，正迅速成为生物医用材料领域的研究热点。镁（Mg）合金是潜在的生物相容性、骨传导性和可生物降解的金属材料，由于其在体内的原位降解、与骨相似的机械性能以及积极刺激新骨形成的能力，其可用于骨修复。然而，这些材料在生理环境中的快速降解可能导致气穴、溶血和骨质溶解，从而阻碍其临床骨科应用。本文就镁合金植入物在骨修复中的应用作一综述。综述了镁合金的合金设计、表面改性及生物学性能等方面的研究进展。未来的挑战和生物医用镁合金用于骨修复的发展进行了讨论。
Bone repair materials are rapidly becoming a hot topic in the field of biomedical materials due to being an important means of repairing human bony deficiencies and replacing hard tissue. Magnesium (Mg) alloys are potentially biocompatible, osteoconductive, and biodegradable metallic materials that can be used in bone repair due to their in situ degradation in the body, mechanical properties similar to those of bones, and ability to positively stimulate the formation of new bones. However, rapid degradation of these materials in physiological environments may lead to gas cavities, hemolysis, and osteolysis and thus, hinder their clinical orthopedic applications. This paper reviews recent work on the use of Mg alloy implants in bone repair. Research to date on alloy design, surface modification, and biological performance of Mg alloys is comprehensively summarized. Future challenges for and developments in biomedical Mg alloys for use in bone repair are also discussed.