Challenges in Ototoxicity Monitoring in the Pediatric Oncology Population
Challenges in Ototoxicity Monitoring in the Pediatric Oncology Population
复制标题
DOI：
10.3766/jaaa.25.8.6
复制
发表时间：
2014-09-01
影响因子：
1.2
通讯作者：
Bhagat, Shaum P.
中科院分区：
文献类型：
--
作者：
Bass, Johnnie K.;Bhagat, Shaum P.
背景：含铂化疗和颅放疗是治疗多种儿童癌症的有效选择。这些疗法可能，而且经常会导致早发性和迟发性不良健康影响，如听力损失。未被发现的听力损失对正在发展言语和语言技能的幼儿尤其重要，并会对幼儿和大龄儿童的学业成绩和心理健康产生负面影响。听力损失的儿科肿瘤患者的早期检测和早期干预是至关重要的，以帮助这些患者成功地实现这些发展的milestones.Purpose：本研究的主要目标是建立一个教程听力学家关于监测耳毒性在儿科肿瘤人口。对接受潜在耳毒性癌症治疗的儿童进行听力监测，对听力学家来说是一个特殊的问题和挑战。本教程将引导读者了解这些特殊问题和挑战，并提出潜在的解决方案。设计：本教程分为几个部分，包括铂化合物和颅放射治疗的概述，通常用于治疗儿科癌症，修改所需的测试电池，以适当监测儿童耳毒性听力损失，监测协议的建议，和描述的分级量表，经常使用的肿瘤学家，以确定耳毒性听力损失的严重程度。结论：耳毒性的识别是至关重要的儿童接受癌症治疗，因为后天性听力损失的影响，在发展中国家的儿童社会和教育成果。儿童听力监测是这一人群所特有的挑战。在开发和验证国际儿科肿瘤学会耳毒性分级量表以供国际使用以报告临床试验中的听觉结局方面，已经做出了大量努力。在未来，标准化监测方案的发展将有助于听力学家为癌症治疗儿童提供最佳护理。
Background: Platinum-based chemotherapy and cranial radiation are effective treatment options commonly prescribed for a variety of childhood cancers. These therapies can, and often do, result in early- and late-onset adverse health effects such as hearing loss. Undetected hearing loss is particularly concerning in young children developing speech and language skills and can negatively affect academic achievement and the psychosocial well-being of both young and older children. Early detection of hearing loss in pediatric oncology patients and early intervention are critical to help these patients succeed in achieving these developmental milestones.Purpose: The primary goal of this study was to create a tutorial for audiologists concerning the monitoring of ototoxicity in the pediatric oncology population. Monitoring hearing for children receiving potentially ototoxic cancer treatments presents special issues and challenges for audiologists. This tutorial will orient the reader to these special issues and challenges, and potential solutions will be proposed.Design: This tutorial is organized into sections, including an overview of platinum compound and cranial radiation treatments commonly used to treat pediatric cancer, modifications of the test battery required to appropriately monitor for ototoxic hearing loss in children, a proposal for a monitoring protocol, and descriptions of the grading scales that are frequently used by oncologists to determine the Severity of ototoxic hearing loss.Conclusions: Identification of ototoxicity is crucial in children receiving cancer treatments because of the impact that acquired hearing loss has on social and educational outcomes in the developing child. Monitoring hearing in children presents challenges that are unique to this population. Much effort has been put forth in developing and validating the International Society of Pediatric Oncology ototoxicity grading scale for international use in reporting auditory outcomes in clinical trials. In the future, the development of standardized monitoring protocols will assist audiologists in providing optimal care to children treated for cancer.