Evidence for a tumoricidal dose level in the radiotherapy of Hodgkin's disease.
Evidence for a tumoricidal dose level in the radiotherapy of Hodgkin's disease.
复制标题
霍奇金病放射治疗中杀肿瘤剂量水平的证据。
作者：
H. Kaplan
对现有证据的审查表明，霍奇金斯病往往在治疗区域复发，其频率与剂量成反比，在约4000拉德的剂量下接近零，以约1000拉德/周的速度给药。为了避免严重的皮肤反应，这样的剂量必须使用超高电压x射线束，但正常组织在其他方面的耐受性良好。复发率与放射剂量的负相关关系对霍奇金淋巴瘤的放射治疗具有重要意义，迄今为止有关放射剂量与霍奇金淋巴瘤长期生存的有限数据支持了这一点。
Summary A review of the available evidence indicates that Hodgkin9s disease tends to recur in a treated field with a frequency which is inversely related to dose and approaches zero at a dose of approximately 4000 rads, delivered at the rate of about 1000 rads/week. Such doses make the use of megavoltage X-ray beams mandatory to avoid severe skin reactions, but are otherwise well tolerated by the normal tissues. The inverse relationship of recurrence rate to radiation dose has important implications for the radiotherapy of Hodgkin9s disease, which are supported by the limited data thus far available relating radiation dose to long term survival in Hodgkin9s disease.