Touching on translation
Touching on translation
复制标题
触及翻译
DOI：
--
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发表时间：
2013
影响因子：
3.6
通讯作者：
T. Steckler
中科院分区：
文献类型：
--
作者：
J. Talpos;T. Steckler
在过去的十年里，“翻译”方法的想法在神经科学领域已经变得司空见惯。尽管这一理论框架得到了迅速的适应，但很少有假设驱动的翻译从临床前的发现开始，以积极的临床结果结束，也没有以这种方式开发出用于治疗认知相关障碍的新药的例子。虽然成功翻译的例子是存在的，但其中大多数都是事后假设检验的结果，而不是先验假设的创造。事实上，临床前和临床结果之间的这种脱节在一定程度上是由临床前水平(对可能与患者群体无关的行为的测量)和临床水平(使用无法在临床前环境中模拟的测试电池的使用)所使用的范式所推动的。然而，需要对视频监视器上显示的刺激做出反应的自动认知电池正在缩短临床前和临床行为研究之间的距离。在过去的5年里，发表了许多论文，证明可以通过配备触摸屏的操作盒在啮齿动物身上以类似于在临床环境中测量认知功能的方式进行测量。在这里，我们认为触摸屏方法有潜力成为一个强大的工具，将临床前的假设转化为积极的临床结果。
During the last decade, the idea of a “translational” approach has become commonplace within the field of neuroscience. Despite the rapid adaptation of this theoretical framework, few examples of hypothesis-driven translation start with a pre-clinical finding and end with a positive clinical result and no examples of a novel medication have been developed in this way for the treatment of cognition-related disorders. Whereas instances of successful translation exist, most of these are the result of post-hoc hypothesis testing, rather than a priori hypothesis creation. Indeed, part of this disconnection between pre-clinical and clinical results has been driven by paradigms used at both the pre-clinical level (measurement of behaviors that might not be relevant to a patient population) and the clinical level (use of test batteries that cannot be modeled in a pre-clinical environment). However, automated cognition batteries that require responses to stimuli displayed upon a video monitor are decreasing the distance between pre-clinical and clinical behavioral studies. In the last 5 years, numerous papers have been published demonstrating that cognitive functions can be measured in a similar manner in the rodent as in a clinical setting via touch-screen-equipped operant boxes. Here, we argue that the touch-screen approach has the potential of being a powerful tool for the translation of pre-clinical hypotheses into positive clinical findings.
影响因子：
3.7
作者：
McCarthy, G;Puce, A;GoldmanRakic, P
通讯作者：
GoldmanRakic, P