Beta-receptors and surface active material flux in fetal lamb lung: female advantage.
Beta-receptors and surface active material flux in fetal lamb lung: female advantage.
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胎儿羔羊肺中的β受体和表面活性物质通量：雌性优势。
DOI：
10.1152/jappl.1987.63.2.828
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Saluna,T
中科院分区：
文献类型：
--
作者：
Warburton,D;Parton,L;Buckley,S;Cosico,L;Saluna,T
我们将雄性和雌性慢性插管胎羊的肺β-肾上腺素能受体的个体发育与表面活性物质(SAM)进入气管液体的开始相关联。SAM通量开始于雌性0.82~0.85孕期和雄性0.85~0.89孕期，此后雌性比雄性更快成熟(P<0.01)。以[~H]二氢阿普洛尔为配基的β-肾上腺素能受体结合是可饱和的、线性的和立体特异性的。竞争性β-激动剂的效力顺序为异丙肾上腺素>去甲肾上腺素>肾上腺素。在0.84~0.89孕龄之间，肺β受体的最大结合容量(Bmax)增加了近一倍，与SAM流量的开始相吻合。女性Bmax与胎龄呈三次多项式关系(r=0.9P<0.001)，男性Bmax与胎龄呈线性关系(r=0.80，P<0.005)。在0.86年至0.93年期间，女性的Bmax是男性的1.45倍(P<0.001)。β受体的解离常数不受性别和孕周的影响。我们得出结论，肺β受体的成熟与胎羊SAM流量的开始是一致的，并且两者在雌性羔羊中成熟得更快。我们推测，肺β受体成熟和SAM流量受激素因素共同调节。女性的肺β受体和SAM流量更快成熟可能是女性在肺表面活性物质成熟和早产儿存活方面的优势的一个因素。
We correlated the ontogeny of pulmonary beta-adrenergic receptors with the onset of surface active material (SAM) flux into tracheal fluid of male and female chronically catheterized fetal lambs. SAM flux began between 0.82 and 0.85 gestation in the females and between 0.85 and 0.89 gestation in the males and matured more rapidly thereafter in the females than in the males (P less than 0.01). beta-Adrenergic receptor binding, using [3H]dihydroalprenolol as the ligand, was saturable, linear, and stereospecific. The order of potency of competitive beta-agonists was isoproterenol greater than norepinephrine greater than epinephrine. The maximal binding capacity (Bmax) of pulmonary beta-receptors approximately doubled between 0.84 and 0.89 gestation, coinciding with the onset of SAM flux. Bmax matured as a third degree polynomial function of gestational age in females (r = 0.9, P less than 0.001) but as a linear function in males (r = 0.8, P less than 0.005). Between 0.86 and 0.93 gestation, Bmax was 1.45-fold greater in females than males (P less than 0.001). The dissociation constant of beta-receptors was not influenced significantly by gender or gestation. We conclude that maturation of pulmonary beta-receptors coincides with the onset of SAM flux in fetal lambs and that both mature more rapidly in females. We speculate that pulmonary beta-receptor maturation and SAM flux are coregulated by hormonal factors. More rapid maturation of pulmonary beta-receptors and SAM flux in females may be a factor in the female advantage with regard to pulmonary surfactant maturation and the survival of premature neonates.