Cellular Strategies of Protein Quality Control
Cellular Strategies of Protein Quality Control
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DOI：
10.1101/cshperspect.a004374
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发表时间：
2011-08-01
影响因子：
7.2
通讯作者：
Frydman, Judith
中科院分区：
文献类型：
--
作者：
Chen, Bryan;Retzlaff, Marco;Frydman, Judith
真核细胞必须与连续的错误折叠蛋白质流竞争，这些蛋白质流损害细胞蛋白质稳态平衡并危及细胞活力。分子伴侣和蛋白质降解因子的复杂网络持续监测和维持蛋白质组的完整性。细胞蛋白质质量控制依赖于三种不同但相互关联的策略，由此错误折叠的蛋白质可以被重折叠、降解或递送到隔离潜在有害的错误折叠种类的不同质量控制隔室。分子伴侣在决定细胞中错误折叠蛋白质的命运方面起着关键作用。在这里，我们讨论了空间和时间组织的细胞质量控制策略及其对人类疾病的影响与蛋白质错误折叠和聚集。
Eukaryotic cells must contend with a continuous stream of misfolded proteins that compromise the cellular protein homeostasis balance and jeopardize cell viability. An elaborate network of molecular chaperones and protein degradation factors continually monitor and maintain the integrity of the proteome. Cellular protein quality control relies on three distinct yet interconnected strategies whereby misfolded proteins can either be refolded, degraded, or delivered to distinct quality control compartments that sequester potentially harmful misfolded species. Molecular chaperones play a critical role in determining the fate of misfolded proteins in the cell. Here, we discuss the spatial and temporal organization of cellular quality control strategies and their implications for human diseases linked to protein misfolding and aggregation.