Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins
Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins
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DOI：
10.1038/s41586-020-2169-0
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发表时间：
2020-03-26
期刊：
影响因子：
64.8
通讯作者：
Cao, Wu-Chun
中科院分区：
文献类型：
--
作者：
Lam, Tommy Tsan-Yuk;Jia, Na;Cao, Wu-Chun
中国和世界各地正在爆发的病毒性肺炎与一种新的冠状病毒SARS-CoV-2(1)有关。这次暴发暂时与中国武汉的一个海鲜市场有关，在那里出售野生动物可能是人畜共患感染的来源(2)。虽然蝙蝠可能是SARS-CoV-2的宿主，但任何可能促进传播给人类的中间宿主的身份尚不清楚。在这里，我们报告在中国南方缉获的马来亚穿山甲（Manisjavanica）中发现了与sars - cov -2相关的冠状病毒。宏基因组测序鉴定出与穿山甲相关的冠状病毒，它们属于SARS-CoV-2相关冠状病毒的两个亚谱系，其中一个在受体结合结构域上与SARS-CoV-2表现出很强的相似性。穿山甲冠状病毒多谱系的发现及其与SARS-CoV-2的相似性表明，应考虑穿山甲是新型冠状病毒出现的可能宿主，应将穿山甲从菜市场移除，以防止人畜共患病传播。
The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-2(1). This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection(2).Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manisjavanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.