Hypoglycemic effect of methanolic extract of Anacardium occidentale leaves in alloxan-induced diabetic rats.
Hypoglycemic effect of methanolic extract of Anacardium occidentale leaves in alloxan-induced diabetic rats.
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西方漆树叶的甲醇提取物对四氧嘧啶诱导的糖尿病大鼠的降血糖作用。
DOI：
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发表时间：
2010
影响因子：
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通讯作者：
K. Odufuwa
中科院分区：
文献类型：
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作者：
T. R. Fagbohun;K. Odufuwa
腰果树叶是一种原产于非洲荒地的植物，被用作治疗糖尿病的民间药物。以往的研究报道了西花莲叶水提物对糖尿病大鼠的降血糖作用及其对链脲佐菌素致糖尿病作用的预防作用。本研究评价了链脲佐菌素叶及其部分的甲醇提取物对四氧嘧啶诱导的糖尿病大鼠的降糖作用，并与参比药物甲苯丁胺进行了比较。对于中度糖尿病的大鼠，西方拟青霉在4小时内引起79.2%的变化，而甲苯丁胺在同一时间段引起63.1%的变化。当大鼠被认为是严重糖尿病时，西方黄鼠的血糖水平在4小时内下降了20.8%，甲苯磺丁胺在4小时内的平均变化百分比为47.63%。这些值被认为并不重要。因此，与参比药物甲苯丁胺相比，西方草药的疗效也可以得出同样的结论。这些结果表明，与甲苯磺丁胺相比，西洋参具有相似的降血糖能力。
Anacardium occidentale Leave (Anacardiaceae), a plant natively grown in wastelands in Africa is used as a folk remedy for diabetes mellitus. Previous studies, reported the hypoglycemic effect of the aqueous leaf extract of A. occidentale in diabetic rats and its prophylactic activity against the diabetogenic action of streptozotocin This study evaluated the hypoglycemic effect of a methanolic extract of streptozotocin leaves and its fractions in Alloxan-induced diabetic rats in comparison to Tolbutamide, a reference drug. For moderately diabetic rat, A. occidentale caused a 79.2 % change over 4 hours and Tolbutamide caused a 63.1 % change over this same time period. When the rat were considered to be severely diabetic, the A. occidentale decreased the blood glucose levels by 20.8% change over four hours and the mean percent change over 4 hours for Tolbutamide was 47.63%. These values were not considered significant. So the same conclusion can be made about the efficacy of A. occidentale, when compared to the reference drug, Tolbutamide. These results that show that A. occidentale has a similar ability compared with Tolbutamide to lower blood glucose levels.